ID   PRF02_KALTU             Reviewed;         133 AA.
AC   E2D0Y9;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Profilin Sal k 4.0201 {ECO:0000305};
DE   AltName: Full=Allergen Sal k 4.02 {ECO:0000303|PubMed:23043287};
DE   AltName: Allergen=Sal k 4.0201 {ECO:0000305};
OS   Kali turgidum (Prickly saltwort) (Salsola kali).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Salsoloideae; Salsoleae; Kali.
OX   NCBI_TaxID=151250 {ECO:0000312|EMBL:ADK22841.1};
RN   [1] {ECO:0000312|EMBL:ADK22841.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, TISSUE SPECIFICITY, AND
RP   ALLERGEN.
RC   TISSUE=Pollen {ECO:0000303|PubMed:23043287, ECO:0000312|EMBL:ADK22841.1};
RX   PubMed=23043287; DOI=10.1111/febs.12024;
RA   Mas S., Barderas R., Colas C., Quiralte J., Rodriguez R., Villalba M.;
RT   "The natural profilin from Russian thistle (Salsola kali) contains a low
RT   IgE-binding ability isoform--molecular and immunological
RT   characterization.";
RL   FEBS J. 279:4338-4349(2012).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations.
CC       {ECO:0000255|RuleBase:RU003908}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000255|RuleBase:RU003908}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P35081}.
CC   -!- TISSUE SPECIFICITY: Expressed in pollen (at protein and mRNA level).
CC       {ECO:0000269|PubMed:23043287}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 24% of
CC       the 165 Spanish patients tested allergic to S.kali and/or C.album
CC       pollen. Reduced (by approximately 35%) IgE-binding capacity compared to
CC       Sal k 4.03 in 86% of the patients who have positive IgE-binding to the
CC       three profilins, Sal k 4.02, Sal k 4.03 and Che a 2.
CC       {ECO:0000269|PubMed:23043287}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000255,
CC       ECO:0000255|RuleBase:RU003909, ECO:0000305}.
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DR   EMBL; GQ427675; ADK22841.1; -; mRNA.
DR   AlphaFoldDB; E2D0Y9; -.
DR   SMR; E2D0Y9; -.
DR   Allergome; 2099; Sal k 4.
DR   Allergome; 8201; Sal k 4.0201.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton; Disulfide bond.
FT   CHAIN           1..133
FT                   /note="Profilin Sal k 4.0201"
FT                   /id="PRO_0000447666"
FT   DISULFID        95..117
FT                   /evidence="ECO:0000250|UniProtKB:Q8H2C9"
SQ   SEQUENCE   133 AA;  14340 MW;  32516E4F06193E3A CRC64;
     MSWQAYVDEH LMCNIEDTGN HLTSSAIVGV DGSIWAQSSN FPQVKPQEIE AINKEFDGPN
     TLAPTGLFLG GEKYMVIQGE PGAVIRGKKG PGGVCIKKTT QALIFGIYDE PVAPGQCNMV
     VERLGDYLIE QGL