PRGH_SALTY
ID PRGH_SALTY Reviewed; 392 AA.
AC P41783;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein PrgH;
GN Name=prgH; OrderedLocusNames=STM2874;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 14028s / SGSG 2262;
RX PubMed=7476203; DOI=10.1111/j.1365-2958.1995.mmi_17010169.x;
RA Pegues D.A., Hantman M.J., Behlau I., Miller S.I.;
RT "PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion
RT genes: evidence for a role in protein secretion.";
RL Mol. Microbiol. 17:169-181(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Required for invasion of epithelial cells.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; U21676; AAB60188.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21754.1; -; Genomic_DNA.
DR PIR; S69788; S69788.
DR RefSeq; NP_461795.1; NC_003197.2.
DR RefSeq; WP_000450192.1; NC_003197.2.
DR PDB; 2Y9J; EM; 6.40 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=177-362.
DR PDB; 3GR0; X-ray; 2.30 A; A/B/C/D=170-362.
DR PDB; 3GR1; X-ray; 2.80 A; A/B/C/D/E/F/G/H=170-392.
DR PDB; 3J1W; EM; -; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=14-119.
DR PDB; 3J1X; EM; -; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=173-363.
DR PDB; 3J6D; EM; -; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-392.
DR PDB; 4G1I; X-ray; 1.85 A; A/B=170-392.
DR PDB; 4G2S; X-ray; 1.86 A; A/B/C/D/E/F=11-119.
DR PDB; 5TCP; EM; 4.30 A; 1/3/5/7/9/A/C/E/G/I/K/M/O/Q/S/U/W/Y/b/d/f/h/j/l=130-392.
DR PDB; 5TCR; EM; 6.30 A; 0/10/2/4/6/8/Q/S/U/W/Y/Z/b/d/f/h/j/l/n/p/r/t/v/x=130-392.
DR PDB; 6DUZ; EM; 3.60 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-392.
DR PDB; 6PEM; EM; 3.50 A; E/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-392.
DR PDB; 6PEP; EM; 3.80 A; E/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-392.
DR PDB; 6Q14; EM; 3.80 A; E/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-392.
DR PDB; 6Q15; EM; 5.15 A; E/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-392.
DR PDB; 6Q16; EM; 4.10 A; E/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-392.
DR PDB; 6UOT; EM; 3.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-392.
DR PDB; 6UOV; EM; 3.50 A; B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f/h/j/l/n/p/r/t=1-392.
DR PDB; 7AH9; EM; 3.30 A; 7A/7B/7C/7D/7E/7F/7G/7H/7I/7J/7K/7L/7M/7N/7O/7P/7Q/7R/7S/7T/7U/7V/7W/7X=1-392.
DR PDB; 7AHI; EM; 3.30 A; 7A/7B/7C/7D/7E/7F/7G/7H/7I/7J/7K/7L/7M/7N/7O/7P/7Q/7R/7S/7T/7U/7V/7W/7X=1-392.
DR PDBsum; 2Y9J; -.
DR PDBsum; 3GR0; -.
DR PDBsum; 3GR1; -.
DR PDBsum; 3J1W; -.
DR PDBsum; 3J1X; -.
DR PDBsum; 3J6D; -.
DR PDBsum; 4G1I; -.
DR PDBsum; 4G2S; -.
DR PDBsum; 5TCP; -.
DR PDBsum; 5TCR; -.
DR PDBsum; 6DUZ; -.
DR PDBsum; 6PEM; -.
DR PDBsum; 6PEP; -.
DR PDBsum; 6Q14; -.
DR PDBsum; 6Q15; -.
DR PDBsum; 6Q16; -.
DR PDBsum; 6UOT; -.
DR PDBsum; 6UOV; -.
DR PDBsum; 7AH9; -.
DR PDBsum; 7AHI; -.
DR AlphaFoldDB; P41783; -.
DR SMR; P41783; -.
DR DIP; DIP-59555N; -.
DR IntAct; P41783; 2.
DR STRING; 99287.STM2874; -.
DR TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P41783; -.
DR EnsemblBacteria; AAL21754; AAL21754; STM2874.
DR GeneID; 1254397; -.
DR KEGG; stm:STM2874; -.
DR PATRIC; fig|99287.12.peg.3030; -.
DR HOGENOM; CLU_054956_0_0_6; -.
DR OMA; HIQFSIS; -.
DR BioCyc; SENT99287:STM2874-MON; -.
DR EvolutionaryTrace; P41783; -.
DR PHI-base; PHI:5021; -.
DR PHI-base; PHI:8371; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013387; T3SS_PrgH/EprH.
DR InterPro; IPR019029; T3SS_PrgH/EprH-like.
DR Pfam; PF09480; PrgH; 1.
DR TIGRFAMs; TIGR02554; PrgH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Virulence.
FT CHAIN 1..392
FT /note="Protein PrgH"
FT /id="PRO_0000058571"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT STRAND 15..22
FT /evidence="ECO:0007829|PDB:4G2S"
FT TURN 23..26
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 33..42
FT /evidence="ECO:0007829|PDB:4G2S"
FT HELIX 43..49
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 54..56
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 59..63
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 65..67
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 71..75
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 82..88
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 91..96
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:4G2S"
FT STRAND 108..114
FT /evidence="ECO:0007829|PDB:4G2S"
FT HELIX 173..177
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 178..180
FT /evidence="ECO:0007829|PDB:3GR0"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:3GR0"
FT STRAND 184..188
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:6UOT"
FT STRAND 194..200
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 201..212
FT /evidence="ECO:0007829|PDB:4G1I"
FT TURN 215..219
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 220..223
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 225..239
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 245..249
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 257..261
FT /evidence="ECO:0007829|PDB:4G1I"
FT TURN 262..264
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 269..282
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 290..294
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 296..309
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 314..319
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 322..329
FT /evidence="ECO:0007829|PDB:4G1I"
FT HELIX 333..350
FT /evidence="ECO:0007829|PDB:4G1I"
FT STRAND 352..361
FT /evidence="ECO:0007829|PDB:4G1I"
SQ SEQUENCE 392 AA; 44460 MW; 6381EED985F33CA9 CRC64;
METSKEKTIT SPGPYIVRLL NSSLNGCEFP LLTGRTLFVV GQSDALTASG QLPDIPADSF
FIPLDHGGVN FEIQVDTDAT EIILHELKEG NSESRSVQLN TPIQVGELLI LIRPESEPWV
PEQPEKLETS AKKNEPRFKN GIVAALAGFF ILGIGTVGTL WILNSPQRQA AELDSLLGQE
KERFQVLPGR DKMLYVAAQN ERDTLWARQV LARGDYDKNA RVINENEENK RISIWLDTYY
PQLAYYRIHF DEPRKPVFWL SRQRNTMSKK ELEVLSQKLR ALMPYADSVN ITLMDDVTAA
GQAEAGLKQQ ALPYSRRNHK GGVTFVIQGA LDDVEILRAR QFVDSYYRTW GGRYVQFAIE
LKDDWLKGRS FQYGAEGYIK MSPGHWYFPS PL
