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ATG14_VANPO
ID   ATG14_VANPO             Reviewed;         337 AA.
AC   A7TJJ8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Autophagy-related protein 14;
GN   Name=ATG14; ORFNames=Kpol_534p20;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and
CC       autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex
CC       I. This complex is essential to recruit the ATG8-phosphatidylinositol
CC       conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal
CC       structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase
CC       complex I to the preautophagosomal structure (PAS) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- DOMAIN: Coiled-Coils at the N-terminal half are essential for
CC       autophagy. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG14 family. {ECO:0000305}.
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DR   EMBL; DS480402; EDO17541.1; -; Genomic_DNA.
DR   RefSeq; XP_001645399.1; XM_001645349.1.
DR   AlphaFoldDB; A7TJJ8; -.
DR   SMR; A7TJJ8; -.
DR   STRING; 436907.A7TJJ8; -.
DR   PRIDE; A7TJJ8; -.
DR   EnsemblFungi; EDO17541; EDO17541; Kpol_534p20.
DR   GeneID; 5545763; -.
DR   KEGG; vpo:Kpol_534p20; -.
DR   eggNOG; ENOG502RY86; Eukaryota.
DR   HOGENOM; CLU_069448_0_0_1; -.
DR   InParanoid; A7TJJ8; -.
DR   OMA; MYCSHCI; -.
DR   OrthoDB; 1202793at2759; -.
DR   PhylomeDB; A7TJJ8; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR023261; Autophagy-related_protein_14.
DR   InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR   Pfam; PF10186; ATG14; 1.
DR   PRINTS; PR02030; AUTOPHGYRP14.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..337
FT                   /note="Autophagy-related protein 14"
FT                   /id="PRO_0000317955"
FT   REGION          5..20
FT                   /note="Cysteine repeats"
FT                   /evidence="ECO:0000250"
FT   COILED          87..153
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   337 AA;  39469 MW;  5EADE4C6ADB8E7E5 CRC64;
     MTIQCSVCRN HVQSMYCAHC INTSPNLLHP LRMQLLMVQQ KNKVLKGKVE DILSHALDKN
     WKSSDNDTEG IILADRLHKL EVLKRTKRNN RVRYRISQLT KRIENKQQRL QSLRLQITTT
     DVAKVSNANK KEIEEIRTKY LQLNEVVKRE QELECQSLVD WFILRKRNSY EIPYTLVFLP
     VVSLKNFHKL PKAVTISSLH KMFQFLEIYS QIISFPLLYK GDEIKEKTIN TDEEIAKLIT
     KLVINVLQIG RFKNLIPKDA IDLVWLLDQY DVDSLFYNVI VNHKMECRVV LFHWTFGKVS
     KVVTETLQLP AGSTTSFPRQ QVGDTYDKDD DMWHIVG
 
 
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