ID   PRGR_RANDY              Reviewed;         711 AA.
AC   Q8AYI2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Progesterone receptor;
DE            Short=PR;
DE   AltName: Full=Nuclear receptor subfamily 3 group C member 3;
DE   AltName: Full=dyPR;
GN   Name=pgr; Synonyms=nr3c3, pr;
OS   Rana dybowskii (Dybovsky's frog) (Korean brown frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=71582 {ECO:0000312|EMBL:AAN63590.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis {ECO:0000269|PubMed:14644654};
RX   PubMed=14644654; DOI=10.1016/j.ygcen.2003.08.003;
RA   Wang L., Sanyal S., Oh D.Y., Kim J.-Y., Ju J.W., Song K.-H., Kim J.W.,
RA   Kwon H.B., Choi H.-S.;
RT   "Molecular cloning and characterization of an amphibian progesterone
RT   receptor from Rana dybowskii.";
RL   Gen. Comp. Endocrinol. 135:142-149(2004).
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC       regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC       {ECO:0000269|PubMed:14644654}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Predominantly nuclear.
CC   -!- TISSUE SPECIFICITY: Expressed in all tissues examined: highly expressed
CC       in testis and brain. Also expressed in heart, lung, liver, kidney,
CC       stomach and small intestine. {ECO:0000269|PubMed:14644654}.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF431813; AAN63590.1; -; mRNA.
DR   AlphaFoldDB; Q8AYI2; -.
DR   SMR; Q8AYI2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR000128; Progest_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF02161; Prog_receptor; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Steroid-binding; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..711
FT                   /note="Progesterone receptor"
FT                   /id="PRO_0000053700"
FT   DOMAIN          457..691
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        348..420
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         348..368
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         384..408
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..347
FT                   /note="Modulating, Pro-Rich"
SQ   SEQUENCE   711 AA;  80126 MW;  51BE8F31754EEF7E CRC64;
     MEDKSKQCLQ DPMCLGIESK HYIGSHGRHQ VDFLEEMVDP GEISLDSLIF QRPEDEVSYQ
     KKGGGPASSD NNELEKVLDS ILDTSSSSHL HPWDDYVIPE FQEISVTSAS STKTLGDLTT
     DKKEAGVWTG TTAVENKSIP SLVPKEQDTL EYSIEGQLEG KGRRHGVLAS RHPTLPPDGK
     MPMLPGSAVY LPGQPRHIEE DNDNYDQKHL SPYPCHSSCS HHDGKIKQED SLYAEYGMPS
     SNPATPGPDP SLEYICKSET AAAYDNFRST LGKSSDKAIP VLPTSSTTSQ NLYQPLSLND
     HQQNAYQSGT VNDAFVPQMH LSYEQYSRPD DPDQSSQYGF DALPRKICLI CSDEASGCHY
     GALTCGSCKV FFKRAIEGQH NYLCAGRNDC IGDKIRRKNC PSCRLKKCCQ AGMVLGGRKF
     KKYNRLKPGR ELDRIATSSP MECQQALTRR VSNSSAQEVQ YFPELLQILQ SIEPEVLYAG
     YDYTKPETPS ALLCSLNQLC ERQLLCVVKW SKSLPGFRNM HIDDQIILLQ YSWMSLMVFA
     MGWRSYKHVS GQMLYFAPDL VLNERRMKDS SFYSLCIAMR QLPQEFVKLQ ISQEEFLCMK
     ALLLLNTIPL EGLKSQSYFD EMRSNYIREL AKAISLRHKG VVASSQRFYH LTKVLDSMHE
     LVKQLHLYCL NTFLQSRALS VEFPEMMTEV ISAQLPKILA GMAKPLIFHK K