ID   PRHG_PENBI              Reviewed;         589 AA.
AC   A0A1E1FFK8;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=MFS-type transporter prhG {ECO:0000303|PubMed:27602587};
DE   AltName: Full=Paraherquonin biosynthesis cluster protein G {ECO:0000303|PubMed:27602587};
GN   Name=prhG {ECO:0000303|PubMed:27602587};
OS   Penicillium brasilianum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=104259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 22354 / NBRC 6234 / CBS 338.59 / FRR 3454 / IMI 68220;
RX   PubMed=27602587; DOI=10.1021/jacs.6b08424;
RA   Matsuda Y., Iwabuchi T., Fujimoto T., Awakawa T., Nakashima Y., Mori T.,
RA   Zhang H., Hayashi F., Abe I.;
RT   "Discovery of key dioxygenases that diverged the paraherquonin and
RT   acetoxydehydroaustin pathways in Penicillium brasilianum.";
RL   J. Am. Chem. Soc. 138:12671-12677(2016).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of paraherquonin, a meroterpenoid with a unique,
CC       highly congested hexacyclic molecular architecture.
CC       {ECO:0000269|PubMed:27602587}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; LC127182; BAV69308.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E1FFK8; -.
DR   SMR; A0A1E1FFK8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..589
FT                   /note="MFS-type transporter prhG"
FT                   /id="PRO_0000449172"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   589 AA;  62788 MW;  C47485DDD5F35720 CRC64;
     MITESREHLQ SKPQNSESII RLDTPDDRPS LECDSLPSGG HSSKVSGGPA SIEGKDVKNV
     SELETCATKA QTPHDEVPIS TSKIIAVVGG LVLAVFCMSL DSTILSTAIP NIVSQFHSQN
     EMGWYVSAYS LTLASFSLAF GKIYTFYSTK TVFLITLSLF EAGSLICGAA PNSLALIIGR
     AIAGIGGTGM YLGALLLVAE ILPFDKIPIT TALLGAMYGI AAVVGPLLGG AFTDYATWRW
     CFYINLPMGG LTFLFVFFFV KRGKDKKRTR EANNIVARFL ELDPIGVALM IPTLVCLLLA
     LEWGGATYSW HSWRLIVLYV VGGCCALGFV GVQIWRQDTA TIPPRLLKNR NILGIILFSF
     CLNGSFVVLA YYLPIWFQSI KGVTAIKSGI MNLPLILTMI ICSMICSTLV TKLGYYTPFL
     YLAPIIASTG AGLLSTMHVN SGSPVWIGFQ ALFGIGLGCG GTLSIVAAQT ALPPEDISTG
     TAIVTFTQTL AAAVFNFVAQ NVFQNQVLSG LAQSAPGVSA AKLTKAGPTM LREVVPADTL
     PAVLEVYNTA ITRAFYVSVG GAALAIFGSI PLQWLSVKDR KTQAVTAHA