PRH_ARATH
ID PRH_ARATH Reviewed; 796 AA.
AC P48785;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Pathogenesis-related homeodomain protein;
DE Short=PRHA;
GN Name=PRH; Synonyms=PRHA; OrderedLocusNames=At4g29940; ORFNames=F27B13.180;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7913642; DOI=10.2307/3869873;
RA Korfhage U., Trezzini G.F., Meier I., Hahlbrock K., Somssich I.E.;
RT "Plant homeodomain protein involved in transcriptional regulation of a
RT pathogen defense-related gene.";
RL Plant Cell 6:695-708(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9351248; DOI=10.1046/j.1365-313x.1997.00635.x;
RA Plesch G., Stoermann K., Tovar Torres J., Walden R., Somssich I.E.;
RT "Developmental and auxin-induced expression of the Arabidopsis prha
RT homeobox gene.";
RL Plant J. 12:635-647(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Specifically binds to the fungal elicitor-responsive DNA
CC element, 5'-CTAATTGTTTA-3', of the gene PR2 promoter.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P48785-1; Sequence=Displayed;
CC -!- INDUCTION: By pathogen infection.
CC -!- SIMILARITY: Belongs to the PHD-associated homeobox family.
CC {ECO:0000305}.
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DR EMBL; L21991; AAA32843.1; -; mRNA.
DR EMBL; U48864; AAC49836.1; -; Genomic_DNA.
DR EMBL; AL050352; CAB43669.1; -; Genomic_DNA.
DR EMBL; AL161575; CAB79752.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85698.1; -; Genomic_DNA.
DR PIR; T08555; T08555.
DR RefSeq; NP_194723.1; NM_119140.2. [P48785-1]
DR AlphaFoldDB; P48785; -.
DR SMR; P48785; -.
DR IntAct; P48785; 1.
DR STRING; 3702.AT4G29940.1; -.
DR iPTMnet; P48785; -.
DR PaxDb; P48785; -.
DR PRIDE; P48785; -.
DR ProteomicsDB; 234841; -. [P48785-1]
DR EnsemblPlants; AT4G29940.1; AT4G29940.1; AT4G29940. [P48785-1]
DR GeneID; 829117; -.
DR Gramene; AT4G29940.1; AT4G29940.1; AT4G29940. [P48785-1]
DR KEGG; ath:AT4G29940; -.
DR Araport; AT4G29940; -.
DR TAIR; locus:2005538; AT4G29940.
DR eggNOG; KOG4299; Eukaryota.
DR InParanoid; P48785; -.
DR OMA; RINQETE; -.
DR OrthoDB; 536362at2759; -.
DR PhylomeDB; P48785; -.
DR PRO; PR:P48785; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; P48785; baseline and differential.
DR Genevisible; P48785; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd15504; PHD_PRHA_like; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR045876; PRHA-like_PHD-finger.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Metal-binding; Nucleus;
KW Plant defense; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..796
FT /note="Pathogenesis-related homeodomain protein"
FT /id="PRO_0000049264"
FT REPEAT 605..631
FT /note="1"
FT REPEAT 632..658
FT /note="2"
FT REPEAT 659..685
FT /note="3"
FT REPEAT 686..712
FT /note="4"
FT REPEAT 713..735
FT /note="5; truncated"
FT ZN_FING 190..247
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT DNA_BIND 452..511
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 34..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..735
FT /note="5 X 27 AA tandem repeats"
FT REGION 738..759
FT /note="Leucine-zipper"
FT COMPBIAS 36..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 90657 MW; 5E61509A0CAD6175 CRC64;
MEESETKGRI SQETDKACVS VERIGSTLLS SFVKKGKEVS NKRNSKQNKR KAEEELCSKS
RTKKYSRGWV RCEEMEEEKV KKTRKRKSKR QQKDNKVEVD DSLRLQRRTR YLLIKMKMQQ
NLIDAYATEG WKGQSREKIR PDKELERARK EILNCKLGLR DAIRQLDLLS SVGSMEEKVI
ASDGSIHHDH IFCAECNSRE AFPDNDIILC DGTCNRAFHQ KCLDPPLETE SIPPGDQGWF
CKFCDCKIEI IDTMNAQIGT HFPVDSNWQD IFNEEASLPI GSEATVNNEA DWPSDDSKDD
DYDPEMRENG GGNSSNVSGD GGGDNDEESI STSLSLSSDG VALSTGSWEG HRLSNMVEQC
ETSNEETVCG PRQRRTVDYT QLYYEMFGKD AVLQEQGSED EDWGPNDRRK RKRESDAGST
LVTMCESSKK DQDVVETLEQ SERDSVSVEN KGGRRRMFRL PRNAVEKLRQ VFAETELPSK
AVRDRLAKEL SLDPEKVNKW FKNTRYMALR NRKTESVKQP GDSKTVSGGD SGPEAVMENN
TETNEVQDTL DDTVPPGFDA TNQNILSPCN NNQEEFQQEN VSFPSPTDES QQYLEQNDSS
FVLVPHEKQS SEISLKTAVE ENETESKMMK EPHEELSSEM SLKTAAEEKE TESKMIEEPH
EELSREMSLK TAVEEKETES KMMEEPHDEL NSEMSLSTAV EEKETGSKMT EESHEELSNE
MSLEEKETGR KMTEEEELEA VMEMLCRTEN KLLDVTQRLD RFKTPKGRKK LGNSSSPLLE
EDSVVYVPIA EIKEKR
