ID   AAA1_RAT                Reviewed;         530 AA.
AC   P63116; Q9CW25; Q9JMH8;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Asc-type amino acid transporter 1;
DE            Short=Asc-1;
DE   AltName: Full=D-serine transporter;
DE   AltName: Full=Solute carrier family 7 member 10;
GN   Name=Slc7a10; Synonyms=Asc1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Forebrain;
RA   Alberati-Giani D., Kew J.N.;
RT   "Cloning and characterization of a D-serine transporter from rat brain.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-independent, high affinity transport of small neutral
CC       D- and L-amino acids and amino acid-related compounds. May play a role
CC       in the modulation of glutamatergic transmission through mobilization of
CC       D-serine at the glutamatergic synapse (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC       protein SLC3A2/4F2hc. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. {ECO:0000305}.
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DR   EMBL; AJ313387; CAC42885.1; -; mRNA.
DR   AlphaFoldDB; P63116; -.
DR   SMR; P63116; -.
DR   STRING; 10116.ENSRNOP00000015205; -.
DR   ChEMBL; CHEMBL4105976; -.
DR   PaxDb; P63116; -.
DR   UCSC; RGD:621672; rat.
DR   RGD; 621672; Slc7a10.
DR   eggNOG; KOG1287; Eukaryota.
DR   InParanoid; P63116; -.
DR   PhylomeDB; P63116; -.
DR   Reactome; R-RNO-210991; Basigin interactions.
DR   Reactome; R-RNO-352230; Amino acid transport across the plasma membrane.
DR   PRO; PR:P63116; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0097440; C:apical dendrite; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0042941; P:D-alanine transport; ISO:RGD.
DR   GO; GO:0042942; P:D-serine transport; ISO:RGD.
DR   GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   Pfam; PF13520; AA_permease_2; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Disulfide bond; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..530
FT                   /note="Asc-type amino acid transporter 1"
FT                   /id="PRO_0000054278"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  57549 MW;  0C5A80BF922DB54D CRC64;
     MRRDSDMASH IQQPGGHGNP GPAPSPSPGP GPGPGASERV ALKKEIGLVS ACTIIIGNII
     GSGIFISPKG VLEHSGSVGL ALFVWVLGGG VTALGSLCYA ELGVAIPKSG GDYAYVTEIF
     GGLAGFLLLW SAVLIMYPTS LAVISMTFSN YVLQPVFPNC IPPATASRVL SMACLMLLTW
     VNSSSVRWAT RIQVIFTGGK LLALSLIITV GFVQIFQGHF EELRPTNAFA FWMTPSVGHL
     ALAFLQGSFA FSGWNFLNYV TEELVDPRKN LPRAIFISIP LVTFVYTFTN VAYFTAMSPQ
     ELLSSNAVAV TFGEKLLGYF SWVMPVSVAL STFGGINGYL FTSSRLCFSG AREGHLPSFL
     AMIHVRRCTP IPALLVCCGA TAVIMLVGDT YTLINYVSFI NYLCYGVTIL GLLVLRWRRP
     ALHRPIKVNL LVPVVYLVFW AFLLVFSFIS EPMVCGVGII IILTGVPIFF LGVFWRSKPK
     CVHRFTESMT RWGQELCFVV YPQGSLEEEE NGPMGQPSPL PITDKPLKTQ