PRIC1_RAT
ID PRIC1_RAT Reviewed; 831 AA.
AC Q71QF9;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Prickle-like protein 1;
DE AltName: Full=REST/NRSF-interacting LIM domain protein 1;
DE Flags: Precursor;
GN Name=Prickle1; Synonyms=Rilp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-135.
RG Program for rat gene discovery and mapping;
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 86-831.
RC TISSUE=Brain;
RX PubMed=14645515; DOI=10.1128/mcb.23.24.9025-9031.2003;
RA Shimojo M., Hersh L.B.;
RT "REST/NRSF-interacting LIM domain protein, a putative nuclear translocation
RT receptor.";
RL Mol. Cell. Biol. 23:9025-9031(2003).
CC -!- FUNCTION: Involved in the planar cell polarity pathway that controls
CC convergent extension during gastrulation and neural tube closure (By
CC similarity). Convergent extension is a complex morphogenetic process
CC during which cells elongate, move mediolaterally, and intercalate
CC between neighboring cells, leading to convergence toward the
CC mediolateral axis and extension along the anteroposterior axis.
CC Necessary for nuclear localization of REST. May serve as nuclear
CC receptor (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with REST. {ECO:0000250|UniProtKB:Q96MT3}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}. Cytoplasm,
CC cytosol {ECO:0000250}. Note=A smaller amount is detected in the
CC cytosol. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ03034.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AW434734; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF399843; AAQ03034.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q71QF9; -.
DR SMR; Q71QF9; -.
DR IntAct; Q71QF9; 1.
DR STRING; 10116.ENSRNOP00000031476; -.
DR iPTMnet; Q71QF9; -.
DR PhosphoSitePlus; Q71QF9; -.
DR PaxDb; Q71QF9; -.
DR PRIDE; Q71QF9; -.
DR RGD; 735090; Prickle1.
DR eggNOG; KOG1704; Eukaryota.
DR InParanoid; Q71QF9; -.
DR PhylomeDB; Q71QF9; -.
DR Reactome; R-RNO-4608870; Asymmetric localization of PCP proteins.
DR PRO; PR:Q71QF9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0031965; C:nuclear membrane; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0035904; P:aorta development; ISO:RGD.
DR GO; GO:0060976; P:coronary vasculature development; ISO:RGD.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:2000691; P:negative regulation of cardiac muscle cell myoblast differentiation; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISO:RGD.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISO:RGD.
DR GO; GO:0006606; P:protein import into nucleus; IDA:RGD.
DR CDD; cd09418; LIM2_Prickle; 1.
DR CDD; cd09420; LIM3_Prickle; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR InterPro; IPR033726; LIM2_prickle.
DR InterPro; IPR033727; LIM3_prickle.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS51303; PET; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; LIM domain; Lipoprotein; Membrane; Metal-binding; Methylation;
KW Nucleus; Phosphoprotein; Prenylation; Reference proteome; Repeat; Zinc.
FT CHAIN 1..828
FT /note="Prickle-like protein 1"
FT /id="PRO_0000075890"
FT PROPEP 829..831
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396714"
FT DOMAIN 14..122
FT /note="PET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT DOMAIN 124..189
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 189..249
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 249..313
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 314..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..831
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 315
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U5C7"
FT MOD_RES 591
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U5C7"
FT MOD_RES 594
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U5C7"
FT MOD_RES 683
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U5C7"
FT MOD_RES 828
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 828
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 115
FT /note="K -> I (in Ref. 1; AW434734)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="M -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="V -> L (in Ref. 1; AW434734)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="M -> I (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 831 AA; 94170 MW; 25B999F11055FBD1 CRC64;
MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV
NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA
MMHAVCEQCG LQMNGGEVAV FASRAGPGVC WRPSCFVCFT CNELLVDLIY FYQDGKIHCG
RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC
GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI
YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF
PGLSGSADDT LSRKLDDVSL SGQGAGFAHE EFWKARVDQE ASEDPEEWAE HEDYMTQLLL
KFGDKNLFQQ PPSEVDMRAS EHWIPDNMVT NKPEAKQNHQ SLASKKYQSD MYWAQSQDGL
GDSAYGSHPG PASSRRLQEL DLDHGAAGYN HDQTQWYEDS LECLSDLKPE QSVRDSMDSL
ALSNITGASV DGESKPRPSL YSLQNFEEIE AEDCEKMSNM GTLNSSMLHR SAESLKSLNS
ELCPEKIIPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GSYDIEIRQP PMSERTRRRV
YHFEERGSRP HHHRHRRSRK SRSDNALNLV TERKYSAKDR LRLYTPDNYE KFIQSKGARE
LQAYMQNANL YGQYAHTTSD YALQNPGMTR FLGLYGDDDD SWCSSSTSSS DSEEEGYFLG
QPIPQPRPQR FTYYTDDLSS PASALPTPQF NQRTTKSKKK KGHRGKNCII S
