PRIC4_HUMAN
ID PRIC4_HUMAN Reviewed; 344 AA.
AC Q2TBC4; A2A3M0; A6PVU1; B3KQ15; Q5T3D4; Q9NSV1;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Prickle-like protein 4;
DE AltName: Full=Overexpressed breast tumor protein;
GN Name=PRICKLE4; Synonyms=C6orf49, OEBT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15702247;
RA Teufel A., Weinmann A., Galle P.R., Lohse A.W.;
RT "Characterization of OEBT, a LIM protein.";
RL Int. J. Mol. Med. 15:513-518(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q2TBC4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TBC4-2; Sequence=VSP_017857;
CC Name=3;
CC IsoId=Q2TBC4-3; Sequence=VSP_039377;
CC -!- TISSUE SPECIFICITY: Expressed in a broad range of normal tissues as
CC well as in hepatocellular carcinoma, breast cancer and prostate cancer
CC tissues. {ECO:0000269|PubMed:15702247}.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000305}.
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DR EMBL; AL137721; CAB70893.1; -; mRNA.
DR EMBL; AK057184; BAG51877.1; -; mRNA.
DR EMBL; AL365205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX04063.1; -; Genomic_DNA.
DR EMBL; BC110459; AAI10460.1; -; mRNA.
DR CCDS; CCDS34449.1; -. [Q2TBC4-3]
DR PIR; T46255; T46255.
DR RefSeq; NP_037529.3; NM_013397.5. [Q2TBC4-3]
DR AlphaFoldDB; Q2TBC4; -.
DR BioGRID; 118997; 17.
DR STRING; 9606.ENSP00000377806; -.
DR iPTMnet; Q2TBC4; -.
DR PhosphoSitePlus; Q2TBC4; -.
DR BioMuta; PRICKLE4; -.
DR MassIVE; Q2TBC4; -.
DR PaxDb; Q2TBC4; -.
DR PeptideAtlas; Q2TBC4; -.
DR PRIDE; Q2TBC4; -.
DR Antibodypedia; 78164; 19 antibodies from 8 providers.
DR DNASU; 29964; -.
DR Ensembl; ENST00000359201.6; ENSP00000352128.6; ENSG00000278224.7. [Q2TBC4-1]
DR Ensembl; ENST00000394259.5; ENSP00000377802.1; ENSG00000278224.7. [Q2TBC4-2]
DR Ensembl; ENST00000394260.2; ENSP00000377803.1; ENSG00000278224.7. [Q2TBC4-1]
DR Ensembl; ENST00000458694.6; ENSP00000404911.1; ENSG00000278224.7. [Q2TBC4-3]
DR GeneID; 29964; -.
DR KEGG; hsa:29964; -.
DR MANE-Select; ENST00000458694.6; ENSP00000404911.1; NM_013397.6; NP_037529.3. [Q2TBC4-3]
DR UCSC; uc011duf.2; human. [Q2TBC4-1]
DR CTD; 29964; -.
DR DisGeNET; 29964; -.
DR GeneCards; PRICKLE4; -.
DR HGNC; HGNC:16805; PRICKLE4.
DR HPA; ENSG00000278224; Low tissue specificity.
DR MIM; 611389; gene.
DR neXtProt; NX_Q2TBC4; -.
DR OpenTargets; ENSG00000124593; -.
DR PharmGKB; PA162400083; -.
DR VEuPathDB; HostDB:ENSG00000278224; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00940000161789; -.
DR HOGENOM; CLU_057441_1_0_1; -.
DR InParanoid; Q2TBC4; -.
DR OMA; KKHCTMC; -.
DR OrthoDB; 642235at2759; -.
DR PhylomeDB; Q2TBC4; -.
DR TreeFam; TF313265; -.
DR PathwayCommons; Q2TBC4; -.
DR BioGRID-ORCS; 29964; 15 hits in 1083 CRISPR screens.
DR GeneWiki; C6orf49; -.
DR GenomeRNAi; 29964; -.
DR Pharos; Q2TBC4; Tdark.
DR PRO; PR:Q2TBC4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q2TBC4; protein.
DR Bgee; ENSG00000278224; Expressed in right lobe of thyroid gland and 92 other tissues.
DR ExpressionAtlas; Q2TBC4; baseline and differential.
DR Genevisible; Q2TBC4; HS.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0031941; C:filamentous actin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0051371; F:muscle alpha-actinin binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0061061; P:muscle structure development; IBA:GO_Central.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; LIM domain; Metal-binding; Reference proteome;
KW Repeat; Zinc.
FT CHAIN 1..344
FT /note="Prickle-like protein 4"
FT /id="PRO_0000231619"
FT DOMAIN 1..81
FT /note="PET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT DOMAIN 82..147
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 148..207
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 253..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..3
FT /note="MSP -> MSVQNSGWPHQEDSPKPQDPGPPANSDSDSGHLPGEDPEDTHA
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039377"
FT VAR_SEQ 224..344
FT /note="ETGLDRTEGRDQTSVNSATLSRTLLAAAGGSSLQTQRGLPGSSPQQENRPGD
FT KAEAPKGQEQCRLETIRDPKDTPFSTCSSSSDSEPEGFFLGERLPQSWKTPGSLQAEDS
FT NASKTHCTMC -> APPPHPPDPSLGARSSHRASLAGAFQGPPEPTPRRGRGCGARLPP
FT RRGRRTPSGGGGGPWRGLSAAAAARTAQGLGGAGGWASPPLAAV (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_017857"
FT VARIANT 266
FT /note="S -> R (in dbSNP:rs28403585)"
FT /id="VAR_056165"
FT CONFLICT 248
FT /note="L -> LL (in Ref. 5; AAI10460)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 37551 MW; BB23045A87A4135F CRC64;
MSPQGPAVLS LGSLCLDTNQ APNWTGLQTL LQQLPPQDID ERYCLALGEE ERAELQLFCA
RRKQEALGQG VARLVLPKLE GHTCEKCREL LKPGEYGVFA ARAGEQRCWH QPCFACQACG
QALINLIYFY HDGQLYCGRH HAELLRPRCP ACDQLIFSWR CTEAEGQRWH ENHFCCQDCA
GPLGGGRYAL PGGSPCCPSC FENRYSDAGS SWAGALEGQA FLGETGLDRT EGRDQTSVNS
ATLSRTLLAA AGGSSLQTQR GLPGSSPQQE NRPGDKAEAP KGQEQCRLET IRDPKDTPFS
TCSSSSDSEP EGFFLGERLP QSWKTPGSLQ AEDSNASKTH CTMC
