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PRIM_NPVAC
ID   PRIM_NPVAC              Reviewed;         266 AA.
AC   P41417;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 68.
DE   RecName: Full=DNA primase;
DE            EC=2.7.7.-;
DE   AltName: Full=Late expression factor 1;
GN   Name=LEF-1; ORFNames=ORF14;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L1;
RX   PubMed=8497062; DOI=10.1128/jvi.67.6.3481-3488.1993;
RA   Passarelli A.L., Miller L.K.;
RT   "Identification and characterization of lef-1, a baculovirus gene involved
RT   in late and very late gene expression.";
RL   J. Virol. 67:3481-3488(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH LEF-2.
RX   PubMed=9060674; DOI=10.1128/jvi.71.4.3114-3119.1997;
RA   Evans J.T., Leisy D.J., Rohrmann G.F.;
RT   "Characterization of the interaction between the baculovirus replication
RT   factors LEF-1 and LEF-2.";
RL   J. Virol. 71:3114-3119(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=11836407; DOI=10.1128/jvi.76.5.2287-2297.2002;
RA   Mikhailov V.S., Rohrmann G.F.;
RT   "Baculovirus replication factor LEF-1 is a DNA primase.";
RL   J. Virol. 76:2287-2297(2002).
CC   -!- FUNCTION: Plays an essential role in viral DNA replication. May
CC       generates single-stranded DNA for both leading and lagging strand
CC       synthesis. The primase initiates primer synthesis and thereby produces
CC       large amount of short RNA primers on the lagging strand that the
CC       polymerase elongates using dNTPs. {ECO:0000269|PubMed:11836407,
CC       ECO:0000269|PubMed:9060674, ECO:0000305}.
CC   -!- SUBUNIT: Interacts with LEF-2. {ECO:0000269|PubMed:9060674}.
CC   -!- SIMILARITY: Belongs to the baculoviridae LEF-1 family. {ECO:0000305}.
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DR   EMBL; L09723; AAA46709.1; -; Genomic_DNA.
DR   EMBL; L22858; AAA66644.1; -; Genomic_DNA.
DR   PIR; F72851; F72851.
DR   RefSeq; NP_054043.1; NC_001623.1.
DR   GeneID; 1403846; -.
DR   KEGG; vg:1403846; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0003896; F:DNA primase activity; IDA:UniProtKB.
DR   GO; GO:0019079; P:viral genome replication; IDA:UniProtKB.
DR   InterPro; IPR016658; DNA_primase_LEF1.
DR   PIRSF; PIRSF016433; Viral_DNA_prim; 1.
PE   1: Evidence at protein level;
KW   Early protein; Reference proteome; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN           1..266
FT                   /note="DNA primase"
FT                   /id="PRO_0000132816"
FT   REGION          244..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   266 AA;  30780 MW;  05ABF515A787D679 CRC64;
     MLVCNYTQKR VDMMWDAIAY NDSRKYAFMT VNARWIHADR YFDTSAQLYS YIVQNKVSDV
     HVKPLDDGGG REWVVDADYK NYVDEHDLML KIYIGATAFL LFYTEENVSR VMYTGNRGFH
     LWLKFTDKFK ITSAQNVRVH RYKAFEKPAK LDSDYIQPGS FAHCVREAVR LYVPHMQDSN
     LDALTLQYWP DVDRDIFCNV NKQIRAPYSY NYKGTKFSRC ITKELLDKLK QCYPGYGTGG
     CGPVTTTTTP SPPKIGSMQT TTKSTT
 
 
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