ATG16_ARATH
ID ATG16_ARATH Reviewed; 509 AA.
AC Q6NNP0; Q9FGS2;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Autophagy-related protein 16 {ECO:0000305};
GN Name=ATG16 {ECO:0000303|PubMed:17204848};
GN OrderedLocusNames=At5g50230 {ECO:0000312|Araport:AT5G50230};
GN ORFNames=K6A12.9 {ECO:0000312|EMBL:BAB09394.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17204848; DOI=10.4161/auto.3595;
RA Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W.;
RT "ATG genes involved in non-selective autophagy are conserved from yeast to
RT man, but the selective Cvt and pexophagy pathways also require organism-
RT specific genes.";
RL Autophagy 3:106-116(2007).
CC -!- FUNCTION: May play a role in autophagy. {ECO:0000250|UniProtKB:Q676U5}.
CC -!- INTERACTION:
CC Q6NNP0; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-25517622, EBI-4426557;
CC Q6NNP0; Q5CCK4: VAL2; NbExp=3; IntAct=EBI-25517622, EBI-15193683;
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB024031; BAB09394.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95914.1; -; Genomic_DNA.
DR EMBL; BT011244; AAR92280.1; -; mRNA.
DR EMBL; BT020329; AAV85684.1; -; mRNA.
DR RefSeq; NP_199834.2; NM_124402.4.
DR AlphaFoldDB; Q6NNP0; -.
DR SMR; Q6NNP0; -.
DR IntAct; Q6NNP0; 2.
DR STRING; 3702.AT5G50230.1; -.
DR PaxDb; Q6NNP0; -.
DR PRIDE; Q6NNP0; -.
DR ProteomicsDB; 246545; -.
DR EnsemblPlants; AT5G50230.1; AT5G50230.1; AT5G50230.
DR GeneID; 835088; -.
DR Gramene; AT5G50230.1; AT5G50230.1; AT5G50230.
DR KEGG; ath:AT5G50230; -.
DR Araport; AT5G50230; -.
DR TAIR; locus:2157762; AT5G50230.
DR eggNOG; KOG0288; Eukaryota.
DR HOGENOM; CLU_000288_57_10_1; -.
DR InParanoid; Q6NNP0; -.
DR OMA; LFVWEVN; -.
DR OrthoDB; 404224at2759; -.
DR PhylomeDB; Q6NNP0; -.
DR PRO; PR:Q6NNP0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6NNP0; baseline and differential.
DR Genevisible; Q6NNP0; AT.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19878; PTHR19878; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Autophagy; Protein transport; Reference proteome; Repeat; Transport;
KW WD repeat.
FT CHAIN 1..509
FT /note="Autophagy-related protein 16"
FT /id="PRO_0000434628"
FT REPEAT 223..262
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 265..304
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 307..347
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 349..388
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 391..430
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 437..478
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 480..509
FT /note="WD 7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 509 AA; 56427 MW; 5B178B57AB66F090 CRC64;
MVQEEKAMEA INDALRALRK RHLLEEGAHA PAISALSKPL ISQGSEWKEK TEKLETELQQ
CYKAQSRLSE QLVIEVAESR TSKAILQEKE LLINDLQKEL TQRREDCTRL QEELEEKTKT
VDVLIAENLE IRSQLEEMTS RVQKAETENK MLIDRWMLQK MQDAERLNEA NDLYEEMLAK
LKANGLETLA RQQVDGIVRR NEDGTDHFVE STIPSTCANR IHAHEGGCGS IVFEYNSGTL
FTGGQDRAVK MWDTNSGTLI KSLYGSLGNI LDMAVTHDNK SVIAATSSNN LFVWDVSSGR
VRHTLTGHTD KVCAVDVSKF SSRHVVSAAY DRTIKLWDLH KGYCTNTVLF TSNCNAICLS
IDGLTVFSGH MDGNLRLWDI QTGKLLSEVA GHSSAVTSVS LSRNGNRILT SGRDNVHNVF
DTRTLEICGT LRASGNRLAS NWSRSCISPD DDYVAAGSAD GSVHVWSLSK GNIVSILKEQ
TSPILCCSWS GIGKPLASAD KNGYVCTWT
