ID   ATG16_DEBHA             Reviewed;         183 AA.
AC   Q6BH63;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Autophagy protein 16;
GN   Name=ATG16; OrderedLocusNames=DEHA2G21054g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Stabilizes the ATG5-ATG12 conjugate which is necessary for
CC       autophagy. The ATG5-ATG12/ATG16 complex is required for efficient
CC       promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8
CC       localization to the pre-autophagosomal structure (PAS). Recruits also
CC       ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic
CC       process and is essential for the survival of cells subjected to severe
CC       ER stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16
CC       complex. Several units of each may be present in this complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q03818}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03818}.
CC   -!- SIMILARITY: Belongs to the ATG16 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90968.1; -; Genomic_DNA.
DR   RefSeq; XP_462458.1; XM_462458.1.
DR   AlphaFoldDB; Q6BH63; -.
DR   SMR; Q6BH63; -.
DR   STRING; 284592.Q6BH63; -.
DR   EnsemblFungi; CAG90968; CAG90968; DEHA2G21054g.
DR   GeneID; 2905407; -.
DR   KEGG; dha:DEHA2G21054g; -.
DR   VEuPathDB; FungiDB:DEHA2G21054g; -.
DR   eggNOG; ENOG502S5CU; Eukaryota.
DR   HOGENOM; CLU_117720_0_0_1; -.
DR   InParanoid; Q6BH63; -.
DR   OMA; NHEIDAR; -.
DR   OrthoDB; 1616621at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR   Pfam; PF08614; ATG16; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..183
FT                   /note="Autophagy protein 16"
FT                   /id="PRO_0000218590"
FT   COILED          44..183
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   183 AA;  21537 MW;  C0C0AD5525FFCD91 CRC64;
     MSDDTEWSED ILNRLNVRDQ YEKKDSRYFK AFSQLSQEAR TNDQASNNDK SIEYNKLLKE
     NNQLKKDNEI LTTSLNQTTI SLEKSDLKIN QLLKSQDQLE RHNTSLNNKI KHLNLEIIEK
     NKSVEILNDE LLLNEIQTNV LNDKITRLSD ENKKLVERWI EKAKSDAEKL NDANEFLESV
     NRK