ID   PRKAG_DICDI             Reviewed;         577 AA.
AC   Q8T277; Q559K2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=5'-AMP-activated protein kinase subunit gamma;
DE            Short=AMPK subunit gamma;
GN   Name=prkag; ORFNames=DDB_G0272542;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: AMPK may be responsible for the regulation of fatty acid
CC       synthesis by phosphorylation of acetyl-CoA carboxylase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 5'-AMP-activated protein kinase gamma
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71195.1; -; Genomic_DNA.
DR   RefSeq; XP_645104.1; XM_640012.1.
DR   AlphaFoldDB; Q8T277; -.
DR   SMR; Q8T277; -.
DR   STRING; 44689.DDB0237813; -.
DR   PaxDb; Q8T277; -.
DR   EnsemblProtists; EAL71195; EAL71195; DDB_G0272542.
DR   GeneID; 8618498; -.
DR   KEGG; ddi:DDB_G0272542; -.
DR   dictyBase; DDB_G0272542; prkag.
DR   eggNOG; KOG1764; Eukaryota.
DR   HOGENOM; CLU_472857_0_0_1; -.
DR   InParanoid; Q8T277; -.
DR   OMA; TFWREIS; -.
DR   PhylomeDB; Q8T277; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-163680; AMPK inhibits chREBP transcriptional activation activity.
DR   Reactome; R-DDI-200425; Carnitine metabolism.
DR   Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR   PRO; PR:Q8T277; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031588; C:nucleotide-activated protein kinase complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016208; F:AMP binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0042149; P:cellular response to glucose starvation; IBA:GO_Central.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0050790; P:regulation of catalytic activity; IBA:GO_Central.
DR   Gene3D; 3.10.580.10; -; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   Pfam; PF00571; CBS; 3.
DR   SMART; SM00116; CBS; 4.
DR   SUPFAM; SSF54631; SSF54631; 2.
DR   PROSITE; PS51371; CBS; 4.
PE   3: Inferred from homology;
KW   CBS domain; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Reference proteome; Repeat.
FT   CHAIN           1..577
FT                   /note="5'-AMP-activated protein kinase subunit gamma"
FT                   /id="PRO_0000376890"
FT   DOMAIN          279..341
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          364..426
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          438..499
FT                   /note="CBS 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          517..574
FT                   /note="CBS 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          45..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  64209 MW;  3FBC56EA649B25A9 CRC64;
     MWYPGDEDEE FTSIIENIEK KETQEIKIKT EKLRQASLNQ LPIEQSEGVG GGELSEYNNN
     TTNNNTPTNT TTTTNTNTTT MNNSNNNNER ILSTSNGFDI RLPPNSIEQP SPSFISSSQD
     GVLTVDPLAV DGEKGNKESQ SPPNGDNQIL NNNNMFFKDI TSLPSTDNKS STNTNNNNNE
     NPLKQTISSS PSKSTTTTTT STSTTTTPSL SSLSSNNNNN SNSNNNYINH SSISTVSEGL
     ENLNLKSGIK KIDSETEKYI EEGKQVFVNF LKGHTCYDVI PISGKVVVLD TKLAVKSAFY
     ALEENGIKSA PLWNSEQHDF TGMITVSDFI DILLYYYKKP KSNNIFQDMG IHRIETFWRE
     ISVERPSSLI STEPETNLYD AASLLLCYKI HRLPVVDKKD TNSILHILTH SRILAFMMKS
     FPQLPEKLLS IPIGSLGIGT FATVVTVMTH TPLVEVLELL SEKKISAVPI IDSETSKIVD
     VYSKSDVTLM SKQGILSPSD LNLPVHQVLS TFTKLWQRPE QIYTCTRFDK LGDVIERCIK
     KRVHRLVCID SSKKVEGILS LSDILNYLLN DVKSINH