ID   PRKA_BACSU              Reviewed;         631 AA.
AC   P39134;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein PrkA;
GN   Name=prkA; OrderedLocusNames=BSU08970;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8626065; DOI=10.1016/0378-1119(95)00758-x;
RA   Fischer C., Geourjon C., Bourson C., Deutscher J.;
RT   "Cloning and characterization of the Bacillus subtilis prkA gene encoding a
RT   novel serine protein kinase.";
RL   Gene 168:55-60(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SIMILARITY: Belongs to the PrkA family. {ECO:0000305}.
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DR   EMBL; X79388; CAA55933.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12725.1; -; Genomic_DNA.
DR   PIR; JC4602; JC4602.
DR   RefSeq; NP_388778.1; NC_000964.3.
DR   RefSeq; WP_003233433.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; P39134; -.
DR   STRING; 224308.BSU08970; -.
DR   PaxDb; P39134; -.
DR   PRIDE; P39134; -.
DR   DNASU; 939250; -.
DR   EnsemblBacteria; CAB12725; CAB12725; BSU_08970.
DR   GeneID; 939250; -.
DR   KEGG; bsu:BSU08970; -.
DR   PATRIC; fig|224308.179.peg.969; -.
DR   eggNOG; COG2766; Bacteria.
DR   InParanoid; P39134; -.
DR   OMA; DFYGMED; -.
DR   PhylomeDB; P39134; -.
DR   BioCyc; BSUB:BSU08970-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013153; Prk_AAA_dom.
DR   InterPro; IPR010650; PrkA_C_dom.
DR   InterPro; IPR016230; Ser_kinase_PrkA.
DR   Pfam; PF08298; AAA_PrkA; 1.
DR   Pfam; PF06798; PrkA; 1.
DR   PIRSF; PIRSF000549; Ser_prot_kin; 1.
DR   SMART; SM00763; AAA_PrkA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..631
FT                   /note="Protein PrkA"
FT                   /id="PRO_0000058575"
SQ   SEQUENCE   631 AA;  72888 MW;  874AD03B0282FB68 CRC64;
     MDILKKIEKY REEEQRLKWE GTFADYLEII KENPMVAQSA HSRVFNMIKD SGIEEIDGRK
     KYSFFDRELF GLEESLERLV EEYFHPAAKR LDVRKRILLL MGPVSGGKST LVTMLKKGLE
     AYTLTDNGAV YAIKGCPMHE DPLHLIPHHL RDDFYREYGI RIEGSLSPLN VMRLEEEYGG
     RIEDVKVERI FFSEDKRTGI GTFSPSDPKS QDIADLTGSI DFSTIAEYGS ESDPRAYRFD
     GELNKANRGM MEFQEMLKCD EKFLWHLLSL TQEGNFKAGR FALISADELI VAHTNETEYR
     SFISNKKNEA LHSRIIVMPV PYNLKVSEEE RIYEKMIAES DVADVHIAPH TLKVAAMFSI
     LTRLKEPKRS DIDLVKKMRL YDGESVEGYN SVDVEDMKKE YNDEGMSGID PRYVINRISS
     TIIRKNMESI NSLDVLRSLK EGLDQHPSIS SEDRERYLNF ISAARKEYDD IAKKEVQKAF
     VYSYEESAKT LMDNYLDNVE AYCNKNKLRD PLTGEEMNPD EKLMRSIEEQ IGISENAKKA
     FREEILIRIS AYARKGKRFD YNSHERLREA IQKKLFADLK DVVKITTSTK TPDEQQLKKV
     NEVVARLIDE HGYNSTSANE LLKYVGSLLN R