ID   PRL1_ALLMI              Reviewed;         199 AA.
AC   P55751;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Prolactin-1;
DE   AltName: Full=Prolactin I;
DE            Short=PRL-I;
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=1399264; DOI=10.1111/j.1399-3011.1992.tb00797.x;
RA   Noso T., Swanson P., Lance V.A., Kawauchi H.;
RT   "Isolation and characterization of glycosylated and non-glycosylated
RT   prolactins from alligator and crocodile.";
RL   Int. J. Pept. Protein Res. 39:250-257(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P55751; -.
DR   SMR; P55751; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted.
FT   CHAIN           1..199
FT                   /note="Prolactin-1"
FT                   /id="PRO_0000181321"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        4..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..174
FT                   /evidence="ECO:0000250"
FT   DISULFID        191..199
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   199 AA;  22756 MW;  632B590ACA397411 CRC64;
     LPICPSGSVN CQVSLGELFD RAVKLSHYIH FLSSEMFNEF DERYAQGRGF ITKAVNGCHN
     ASLTTPEDKE QAQQIHHEDL LNLVLGVLRS WNDPLLHLVT EVQRIKEAPD TILWKAVEIE
     EQNKRLLEGM EKIVGRVQPG DTGNEVYSRW SGLPSLQLAD EDSRLFAFYN LLHCGRRDSH
     KIDNYLKLLK CRLIHDSNC