ID   PRL1_ONCTS              Reviewed;         211 AA.
AC   P69131; P09583; P15470;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Prolactin-1;
DE   AltName: Full=Prolactin I;
DE            Short=PRL-I;
DE   Flags: Precursor;
GN   Name=prl1;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3349998; DOI=10.1111/j.1432-1033.1988.tb13884.x;
RA   Song S., Trinh K.-Y., Hew C.-L., Hwang S.J., Belkhode S., Idler D.R.;
RT   "Molecular cloning and expression of salmon prolactin cDNA.";
RL   Eur. J. Biochem. 172:279-285(1988).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M36267; AAB03564.1; -; mRNA.
DR   PIR; S00359; S00359.
DR   AlphaFoldDB; P69131; -.
DR   SMR; P69131; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; ISS:AgBase.
DR   GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; ISS:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISS:AgBase.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; ISS:AgBase.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:AgBase.
DR   GO; GO:0060267; P:positive regulation of respiratory burst; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..211
FT                   /note="Prolactin-1"
FT                   /id="PRO_0000032942"
FT   DISULFID        69..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..211
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   211 AA;  23559 MW;  ABC6B300AAD5590F CRC64;
     MARRSQGTKL HLAVLCLVVS CHAIGLSDLM ERASQRSDKL HSLSTSLTKD LDSHFPPMGR
     VMMPRPSMCH TSSLQTPKDK EQALKVSENE LISLARYLLL AWNDPLLLLS SEAPTLPHTP
     SNGDISSKIR ELQDYSKSLG DGLDIMVNKM GPSSQYISSI PFKGGDLGND KTSRLINFHF
     LMSCFRRDSH KIDSFLKVLR CRATNMRPET C