ID   PRL1_OREMO              Reviewed;         212 AA.
AC   P09319;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Prolactin-1;
DE   AltName: Full=PRL-188;
DE   AltName: Full=Prolactin I;
DE   Flags: Precursor;
GN   Name=prl1;
OS   Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2670495; DOI=10.1089/dna.1.1989.8.261;
RA   Rentier-Delrue F., Swennen D., Prunet P., Lion M., Martial J.A.;
RT   "Tilapia prolactin: molecular cloning of two cDNAs and expression in
RT   Escherichia coli.";
RL   DNA 8:261-270(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Sperm;
RX   PubMed=1418624; DOI=10.1089/dna.1992.11.673;
RA   Swennen D., Poncelet A.C., Sekkali B., Rentier-Delrue F., Martial J.A.,
RA   Belayew A.;
RT   "Structure of the tilapia (Oreochromis mossambicus) prolactin I gene.";
RL   DNA Cell Biol. 11:673-684(1992).
RN   [3]
RP   PROTEIN SEQUENCE OF 25-212.
RC   TISSUE=Pituitary;
RX   PubMed=3379064; DOI=10.1016/s0021-9258(19)76515-6;
RA   Yamaguchi K., Specker J.L., King D.S., Yokoo Y., Nishioka R.S., Hirano T.,
RA   Bern H.A.;
RT   "Complete amino acid sequences of a pair of fish (tilapia) prolactins,
RT   tPRL177 and tPRL188.";
RL   J. Biol. Chem. 263:9113-9121(1988).
RN   [4]
RP   PROTEIN SEQUENCE OF 25-52.
RC   TISSUE=Pituitary;
RX   PubMed=3865172; DOI=10.1073/pnas.82.22.7490;
RA   Specker J.L., King D.S., Nishioka R.S., Shirahata K., Yamaguchi K.,
RA   Bern H.A.;
RT   "Isolation and partial characterization of a pair of prolactins released in
RT   vitro by the pituitary of a cichlid fish, Oreochromis mossambicus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:7490-7494(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M27010; AAA53281.1; -; mRNA.
DR   EMBL; X92380; CAA63124.1; -; Genomic_DNA.
DR   PIR; A32477; A32477.
DR   PIR; B24743; B24743.
DR   PIR; B28106; B28106.
DR   PIR; I51034; I51034.
DR   AlphaFoldDB; P09319; -.
DR   SMR; P09319; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:3379064,
FT                   ECO:0000269|PubMed:3865172"
FT   CHAIN           25..212
FT                   /note="Prolactin-1"
FT                   /id="PRO_0000032944"
FT   DISULFID        70..185
FT   DISULFID        202..212
FT   CONFLICT        2
FT                   /note="A -> R (in Ref. 1; AAA53281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="T -> S (in Ref. 1; AAA53281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124
FT                   /note="T -> S (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   212 AA;  23530 MW;  BB7162F106044D9F CRC64;
     MAQRRTSGTN LFMTVLCVVA MCRAVPINEL FERASQHSDK LHSLSTTLTQ ELDSHFPPIG
     RVIMPRPAMC HTSSLQTPID KDQALQVSES DLMSLARSLL QAWSDPLVVL SSSASTLPHP
     AQSTIFNKIQ EMQQYSKSLK DGLDVLSSKM GSPAQAITSL PYRGGTNLGH DKITKLINFN
     FLLSCLRRDS HKIDSFLKVL RCRAAKMQPE MC