ID   PRL2_ARATH              Reviewed;         479 AA.
AC   Q39190; Q5PNR9; Q940Q7; Q9LUR9;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Protein pleiotropic regulator PRL2;
GN   Name=PRL2; OrderedLocusNames=At3g16650; ORFNames=MGL6.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9765207; DOI=10.1101/gad.12.19.3059;
RA   Nemeth K., Salchert K., Putnoky P., Bhalerao R., Koncz-Kalman Z.,
RA   Stankovic-Stangeland B., Bako L., Mathur J., Oekresz L., Stabel S.,
RA   Geigenberger P., Stitt M., Redei G.P., Schell J., Koncz C.;
RT   "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD
RT   protein, in Arabidopsis.";
RL   Genes Dev. 12:3059-3073(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   DWD MOTIF.
RX   PubMed=18223036; DOI=10.1105/tpc.107.055418;
RA   Lee J.H., Terzaghi W., Gusmaroli G., Charron J.B., Yoon H.J., Chen H.,
RA   He Y.J., Xiong Y., Deng X.W.;
RT   "Characterization of Arabidopsis and rice DWD proteins and their roles as
RT   substrate receptors for CUL4-RING E3 ubiquitin ligases.";
RL   Plant Cell 20:152-167(2008).
CC   -!- FUNCTION: Pleiotropic regulator. {ECO:0000250}.
CC   -!- DOMAIN: The DWD box is required for interaction with DDB1A.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL06842.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB02756.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; X82826; CAA58033.1; -; mRNA.
DR   EMBL; AB022217; BAB02756.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE75848.1; -; Genomic_DNA.
DR   EMBL; AY054181; AAL06842.1; ALT_INIT; mRNA.
DR   EMBL; BT020378; AAV85733.1; -; mRNA.
DR   RefSeq; NP_566557.1; NM_112538.5.
DR   AlphaFoldDB; Q39190; -.
DR   SMR; Q39190; -.
DR   BioGRID; 6251; 2.
DR   IntAct; Q39190; 1.
DR   STRING; 3702.AT3G16650.1; -.
DR   PaxDb; Q39190; -.
DR   PRIDE; Q39190; -.
DR   ProteomicsDB; 226500; -.
DR   EnsemblPlants; AT3G16650.1; AT3G16650.1; AT3G16650.
DR   GeneID; 820917; -.
DR   Gramene; AT3G16650.1; AT3G16650.1; AT3G16650.
DR   KEGG; ath:AT3G16650; -.
DR   Araport; AT3G16650; -.
DR   TAIR; locus:2089303; AT3G16650.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_000288_72_2_1; -.
DR   InParanoid; Q39190; -.
DR   OMA; DDHSVKC; -.
DR   OrthoDB; 1157847at2759; -.
DR   PhylomeDB; Q39190; -.
DR   PRO; PR:Q39190; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q39190; baseline and differential.
DR   Genevisible; Q39190; AT.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045241; Prp46/PLRG1-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19923; PTHR19923; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..479
FT                   /note="Protein pleiotropic regulator PRL2"
FT                   /id="PRO_0000051158"
FT   REPEAT          168..198
FT                   /note="WD 1"
FT   REPEAT          210..240
FT                   /note="WD 2"
FT   REPEAT          252..282
FT                   /note="WD 3"
FT   REPEAT          293..323
FT                   /note="WD 4"
FT   REPEAT          335..364
FT                   /note="WD 5"
FT   REPEAT          377..406
FT                   /note="WD 6"
FT   REPEAT          426..456
FT                   /note="WD 7"
FT   REGION          458..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           269..284
FT                   /note="DWD box 1"
FT   MOTIF           310..325
FT                   /note="DWD box 2"
SQ   SEQUENCE   479 AA;  53568 MW;  301986A4AEA80670 CRC64;
     MTMIALNREV ETQSLKKLSL KSVRRAREIF SPVHGQFPQP DPESKRIRLC HKIQVAFGGV
     EPASKPTRIA DHNSEKTAPL KALALPGPKG SKELRKSATE KALVVGPTLP PRDLNNTGNP
     GKSTAILPAP GSFSERNLST AALMERMPSR WPRPEWHAPW KNYRVLQGHL GWVRSVAFDP
     SNEWFCTGSA DRTIKIWDVA TGVLKLTLTG HIGQVRGLAV SNRHTYMFSA GDDKQVKCWD
     LEQNKVIRSY HGHLHGVYCL ALHPTLDVVL TGGRDSVCRV WDIRTKMQIF VLPHDSDVFS
     VLARPTDPQV ITGSHDSTIK FWDLRYGKSM ATITNHKKTV RAMALHPKEN DFVSASADNI
     KKFSLPKGEF CHNMLSLQRD IINAVAVNED GVMVTGGDKG GLWFWDWKSG HNFQRAETIV
     QPGSLESEAG IYAACYDQTG SRLVTCEGDK TIKMWKEDED ATPETHPLNF KPPKEIRRF