ID   PRL2_ONCTS              Reviewed;         210 AA.
AC   Q91364;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Prolactin-2;
DE   AltName: Full=Prolactin II;
DE            Short=PRL-II;
DE   Flags: Precursor;
GN   Name=prl2;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1308811;
RA   Xiong F., Chin R.A., Hew C.-L.;
RT   "A gene encoding chinook salmon (Oncorhynchus tschawytscha) prolactin: gene
RT   structure and potential cis-acting regulatory elements.";
RL   Mol. Mar. Biol. Biotechnol. 1:155-164(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S66606; AAB28216.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q91364; -.
DR   SMR; Q91364; -.
DR   Ensembl; ENSOTST00005024354; ENSOTSP00005022475; ENSOTSG00005010731.
DR   GeneTree; ENSGT00950000182818; -.
DR   OrthoDB; 1290070at2759; -.
DR   Proteomes; UP000694402; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; ISS:AgBase.
DR   GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; ISS:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISS:AgBase.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; ISS:AgBase.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:AgBase.
DR   GO; GO:0060267; P:positive regulation of respiratory burst; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..210
FT                   /note="Prolactin-2"
FT                   /id="PRO_0000032943"
FT   DISULFID        69..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..210
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23457 MW;  C3C0DBB0D87EA7B5 CRC64;
     MARRSQGTKL HLAVLCLVVS CHAIGLSDLM ERASQRSDKL HSLSTSLNKD LDSHFPPMGR
     VMMPRPSMCH TSSLQIPKDK EQALRVSENE LISLARSLLL AWNDPLLLLS SEAPTLPHPS
     NGDISSKIRE LQDYSKSLGD GLDILVNKMG PSSQYISLIP FKGGDLGNDK TSRLINFHFL
     MSCFRRDSHK IDSFLKVLRC RATKMRPETC