ID   PRLA_DICDI              Reviewed;         385 AA.
AC   Q1ZXG4; Q23918;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Proliferation-associated protein A;
GN   Name=prlA; ORFNames=DDB_G0282361;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-385.
RC   STRAIN=AX4;
RX   PubMed=8643615; DOI=10.1073/pnas.93.11.5562;
RA   Kuspa A., Loomis W.F.;
RT   "Ordered yeast artificial chromosome clones representing the Dictyostelium
RT   discoideum genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996).
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000047; EAS66866.1; -; Genomic_DNA.
DR   EMBL; U61403; AAB03665.1; -; mRNA.
DR   RefSeq; XP_001134549.1; XM_001134549.1.
DR   AlphaFoldDB; Q1ZXG4; -.
DR   SMR; Q1ZXG4; -.
DR   STRING; 44689.DDB0232955; -.
DR   PaxDb; Q1ZXG4; -.
DR   EnsemblProtists; EAS66866; EAS66866; DDB_G0282361.
DR   GeneID; 8623602; -.
DR   KEGG; ddi:DDB_G0282361; -.
DR   dictyBase; DDB_G0282361; prlA.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_041451_2_1_1; -.
DR   InParanoid; Q1ZXG4; -.
DR   OMA; HTVLLMP; -.
DR   PhylomeDB; Q1ZXG4; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   PRO; PR:Q1ZXG4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR004545; PA2G4.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR001714; Pept_M24_MAP.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   PRINTS; PR00599; MAPEPTIDASE.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
DR   TIGRFAMs; TIGR00495; crvDNA_42K; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..385
FT                   /note="Proliferation-associated protein A"
FT                   /id="PRO_0000327982"
FT   CONFLICT        380
FT                   /note="I -> T (in Ref. 2; AAB03665)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   385 AA;  42306 MW;  69DB4B686234C58E CRC64;
     MSNKDQEIKE EAPVAIEDLS NPVVVDSYNA AGIIANNAIK HVISKCVVGA LVVDICQYGD
     DFIEAEAAKT FTKRKNLEKG IAFPTCVSVN NCVGHFSPLK GNTRTLKQGD VVKIDLGCHI
     DGYIAVGAHT IIIGNTSAES MTGKVADAIC AAHYALEAAL RMIRPGKTSN EVTQVIEKIS
     DMYGVTSVSG ILSHELKRFI IDGEKVIFSK NEPSQKIQTY EFQENEVYCI DIVMSTGEGK
     AREEADRPTI YRRNLDSTYK LKSKASRDFK DQIVKRYSAL PFPLRNFDEK VSKLGLVELV
     EHQVLAAYPV LFDRSGCEVV QFKTTVLVLP NGNHKLIGTE FPLPFVRSEF SVTDDAIKAL
     IASPLKINKK AAKKASATTI DVKMQ