ID   ATG16_MAGO7             Reviewed;         204 AA.
AC   Q520U5; A4QSV8; G4N5E8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Autophagy protein 16;
GN   Name=ATG16; ORFNames=MGG_05255;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Stabilizes the ATG5-ATG12 conjugate which is necessary for
CC       autophagy. The ATG5-ATG12/ATG16 complex is required for efficient
CC       promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8
CC       localization to the pre-autophagosomal structure (PAS). Recruits also
CC       ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic
CC       process and is essential for the survival of cells subjected to severe
CC       ER stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16
CC       complex. Several units of each may be present in this complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q03818}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03818}.
CC   -!- SIMILARITY: Belongs to the ATG16 family. {ECO:0000305}.
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DR   EMBL; CM001233; EHA53005.1; -; Genomic_DNA.
DR   RefSeq; XP_003712812.1; XM_003712764.1.
DR   AlphaFoldDB; Q520U5; -.
DR   SMR; Q520U5; -.
DR   STRING; 318829.MGG_05255T0; -.
DR   EnsemblFungi; MGG_05255T0; MGG_05255T0; MGG_05255.
DR   GeneID; 2675466; -.
DR   KEGG; mgr:MGG_05255; -.
DR   VEuPathDB; FungiDB:MGG_05255; -.
DR   eggNOG; ENOG502S5CU; Eukaryota.
DR   HOGENOM; CLU_082752_1_0_1; -.
DR   InParanoid; Q520U5; -.
DR   OMA; QACSQMA; -.
DR   OrthoDB; 1616621at2759; -.
DR   PHI-base; PHI:2082; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR   Pfam; PF08614; ATG16; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..204
FT                   /note="Autophagy protein 16"
FT                   /id="PRO_0000218593"
FT   REGION          50..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          24..183
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        54..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  22465 MW;  FFF9B3F06AD08359 CRC64;
     MSSLPDWRDE YLASIKEAEK NSPVNRDLVE ACSQLQDRVA ALEAERDALK ASGASAGQSA
     SDPASQSGDA AQSAVVARLR LDLAEALGTQ ERLQSRLGLA ESELERLRAK TAEDAKTIRT
     LNTQCVSLST KVKDRNEELQ GKSKLVENVQ DELIALTLQL NVMEQQKAKI QAENDQLVER
     WMKRMGQEAE AMNLANEPKF AKRG