ID   PRLD1_BOVIN             Reviewed;         219 AA.
AC   Q32KN9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=PRELI domain-containing protein 1, mitochondrial;
DE   Flags: Precursor;
GN   Name=PRELID1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the modulation of the mitochondrial apoptotic
CC       pathway by ensuring the accumulation of cardiolipin (CL) in
CC       mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates
CC       the transfer of phosphatidic acid (PA) between liposomes and probably
CC       functions as a PA transporter across the mitochondrion intermembrane
CC       space to provide PA for CL synthesis in the inner membrane. Regulates
CC       the mitochondrial apoptotic pathway in primary Th cells. Regulates Th
CC       cell differentiation by down-regulating STAT6 thereby reducing IL-4-
CC       induced Th2 cell number. May be important for the development of vital
CC       and immunocompetent organs (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y255}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-
CC         glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608;
CC         Evidence={ECO:0000250|UniProtKB:Q9Y255};
CC   -!- SUBUNIT: Forms a complex with TRIAP1 in the mitochondrion intermembrane
CC       space. Interacts with OPA1 and AIFM1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y255}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9Y255}.
CC       Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y255}.
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DR   EMBL; BC110001; AAI10002.1; -; mRNA.
DR   RefSeq; NP_001033227.1; NM_001038138.2.
DR   AlphaFoldDB; Q32KN9; -.
DR   SMR; Q32KN9; -.
DR   STRING; 9913.ENSBTAP00000006594; -.
DR   PaxDb; Q32KN9; -.
DR   PRIDE; Q32KN9; -.
DR   Ensembl; ENSBTAT00000006594; ENSBTAP00000006594; ENSBTAG00000005009.
DR   GeneID; 523609; -.
DR   KEGG; bta:523609; -.
DR   CTD; 27166; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005009; -.
DR   VGNC; VGNC:33306; PRELID1.
DR   eggNOG; KOG3337; Eukaryota.
DR   GeneTree; ENSGT00950000182810; -.
DR   HOGENOM; CLU_067902_3_0_1; -.
DR   InParanoid; Q32KN9; -.
DR   OMA; LAFFNRY; -.
DR   OrthoDB; 1369397at2759; -.
DR   TreeFam; TF313119; -.
DR   Reactome; R-BTA-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000005009; Expressed in ileocecal valve and 105 other tissues.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR   GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR   GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR   GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR   GO; GO:1901857; P:positive regulation of cellular respiration; ISS:UniProtKB.
DR   GO; GO:0010950; P:positive regulation of endopeptidase activity; ISS:UniProtKB.
DR   GO; GO:2001140; P:positive regulation of phospholipid transport; ISS:UniProtKB.
DR   GO; GO:0070234; P:positive regulation of T cell apoptotic process; ISS:UniProtKB.
DR   GO; GO:0097035; P:regulation of membrane lipid distribution; ISS:UniProtKB.
DR   GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR   GO; GO:0045580; P:regulation of T cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   InterPro; IPR037365; Slowmo/Ups.
DR   PANTHER; PTHR11158; PTHR11158; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Lipid transport; Mitochondrion; Reference proteome;
KW   Transit peptide; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y255"
FT   CHAIN           ?..219
FT                   /note="PRELI domain-containing protein 1, mitochondrial"
FT                   /id="PRO_0000288433"
FT   DOMAIN          36..174
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
SQ   SEQUENCE   219 AA;  25248 MW;  94627C46367561D4 CRC64;
     MVKYFLGQSV LRSSWDQVFA AFWQRYPNPY SKHVLTEDIV HREVTSDQKL LSRRLLTKTN
     RMPRWAERLF PANVAHSVYI LEDSIVDPQN QTMTTFTWNI NHARLMVVEE RCVYRVNSDN
     SGWTEIRREA WVSSSLFGVS RAVQEFGLAR FKSNVTKTMK GFEYILAKLQ GEAPPKTLVE
     TAKEAKEKAK ETALAATEKA KDLASKAATK KQQQQQQFV