ID   PRLD1_CHICK             Reviewed;         215 AA.
AC   Q90673;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=PRELI domain-containing protein 1, mitochondrial;
DE   AltName: Full=Px19-like protein;
DE   Flags: Precursor;
GN   Name=PRELID1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   FUNCTION.
RC   TISSUE=Heart;
RX   PubMed=8917097; DOI=10.1016/0378-1119(96)00146-1;
RA   Niu S., Antin P.B., Morkin E.;
RT   "Cloning and sequencing of a developmentally regulated avian mRNA
RT   containing the LEA motif found in plant seed proteins.";
RL   Gene 175:187-191(1996).
CC   -!- FUNCTION: Involved in the modulation of the mitochondrial apoptotic
CC       pathway by ensuring the accumulation of cardiolipin (CL) in
CC       mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions
CC       as a PA transporter across the mitochondrion intermembrane space to
CC       provide PA for CL synthesis in the inner membrane (By similarity). May
CC       be involved in hematopoiesis during avian development.
CC       {ECO:0000250|UniProtKB:Q9Y255, ECO:0000305|PubMed:8917097}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-
CC         glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608;
CC         Evidence={ECO:0000250|UniProtKB:Q9Y255};
CC   -!- SUBUNIT: Forms a complex with TRIAP1 in the mitochondrion intermembrane
CC       space. {ECO:0000250|UniProtKB:Q9Y255}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9Y255}.
CC       Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y255}.
CC   -!- TISSUE SPECIFICITY: Expressed within the blood islands and in the
CC       liver. {ECO:0000269|PubMed:8917097}.
CC   -!- DEVELOPMENTAL STAGE: Restricted to developing blood cells.
CC       {ECO:0000269|PubMed:8917097}.
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DR   EMBL; U31977; AAC60046.1; -; mRNA.
DR   PIR; JC5048; JC5048.
DR   AlphaFoldDB; Q90673; -.
DR   SMR; Q90673; -.
DR   STRING; 9031.ENSGALP00000004724; -.
DR   PaxDb; Q90673; -.
DR   VEuPathDB; HostDB:geneid_395819; -.
DR   eggNOG; KOG3337; Eukaryota.
DR   InParanoid; Q90673; -.
DR   PhylomeDB; Q90673; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   InterPro; IPR037365; Slowmo/Ups.
DR   PANTHER; PTHR11158; PTHR11158; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Lipid transport; Mitochondrion; Reference proteome;
KW   Transit peptide; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y255"
FT   CHAIN           ?..215
FT                   /note="PRELI domain-containing protein 1, mitochondrial"
FT                   /id="PRO_0000097118"
FT   DOMAIN          36..174
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
SQ   SEQUENCE   215 AA;  24547 MW;  F6F5AB4386DFF69F CRC64;
     MGKYCASLGV LKGPWDQVFA AFWQRYPNPY SKHVLTEDIV HREVTADHKL LSRRLLTKTN
     RMPRWAERFF PANVAHNVYI VEDSIVDPKN RTMTTFTWNI NHARLMAVEE RCVYRVNPEN
     SSWTEVKREA WVSSSLFGVS RAVQEFGLAR FKSNVTKSTK GFEYVLARMQ GEAPSKTLVE
     TAKEATEKAK ETALAATEKA KDLASKAATK KKQFV