PRLD2_HUMAN
ID PRLD2_HUMAN Reviewed; 189 AA.
AC Q8N945; G5EA01; Q96EQ3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=PRELI domain-containing protein 2;
GN Name=PRELID2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Melanoma, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N945-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N945-2; Sequence=VSP_028824, VSP_028825;
CC Name=3;
CC IsoId=Q8N945-3; Sequence=VSP_044841;
CC -!- SEQUENCE CAUTION:
CC Sequence=BQ425760; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK095695; BAC04611.1; -; mRNA.
DR EMBL; AC008631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61857.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61858.1; -; Genomic_DNA.
DR EMBL; BC012033; AAH12033.1; -; mRNA.
DR EMBL; BQ425760; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS34261.1; -. [Q8N945-3]
DR CCDS; CCDS34262.1; -. [Q8N945-1]
DR CCDS; CCDS43377.1; -. [Q8N945-2]
DR RefSeq; NP_612501.3; NM_138492.5. [Q8N945-2]
DR RefSeq; NP_892005.1; NM_182960.3. [Q8N945-1]
DR RefSeq; NP_995318.1; NM_205846.2. [Q8N945-3]
DR RefSeq; XP_016864618.1; XM_017009129.1. [Q8N945-1]
DR RefSeq; XP_016864619.1; XM_017009130.1. [Q8N945-1]
DR RefSeq; XP_016864620.1; XM_017009131.1. [Q8N945-1]
DR AlphaFoldDB; Q8N945; -.
DR SMR; Q8N945; -.
DR BioGRID; 127516; 17.
DR STRING; 9606.ENSP00000335675; -.
DR iPTMnet; Q8N945; -.
DR PhosphoSitePlus; Q8N945; -.
DR BioMuta; PRELID2; -.
DR DMDM; 74729598; -.
DR MassIVE; Q8N945; -.
DR PaxDb; Q8N945; -.
DR PeptideAtlas; Q8N945; -.
DR PRIDE; Q8N945; -.
DR ProteomicsDB; 34099; -.
DR ProteomicsDB; 72486; -. [Q8N945-1]
DR ProteomicsDB; 72487; -. [Q8N945-2]
DR Antibodypedia; 27490; 93 antibodies from 16 providers.
DR DNASU; 153768; -.
DR Ensembl; ENST00000334744.8; ENSP00000335675.4; ENSG00000186314.12. [Q8N945-1]
DR Ensembl; ENST00000394450.6; ENSP00000377965.2; ENSG00000186314.12. [Q8N945-2]
DR Ensembl; ENST00000505416.5; ENSP00000424730.1; ENSG00000186314.12. [Q8N945-3]
DR Ensembl; ENST00000683046.1; ENSP00000506938.1; ENSG00000186314.12. [Q8N945-3]
DR GeneID; 153768; -.
DR KEGG; hsa:153768; -.
DR MANE-Select; ENST00000683046.1; ENSP00000506938.1; NM_205846.3; NP_995318.1. [Q8N945-3]
DR UCSC; uc003lno.3; human. [Q8N945-1]
DR CTD; 153768; -.
DR DisGeNET; 153768; -.
DR GeneCards; PRELID2; -.
DR HGNC; HGNC:28306; PRELID2.
DR HPA; ENSG00000186314; Tissue enhanced (intestine, retina).
DR neXtProt; NX_Q8N945; -.
DR OpenTargets; ENSG00000186314; -.
DR PharmGKB; PA162400041; -.
DR VEuPathDB; HostDB:ENSG00000186314; -.
DR eggNOG; ENOG502RYVE; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_6_0_1; -.
DR InParanoid; Q8N945; -.
DR OMA; HQVYRYP; -.
DR OrthoDB; 1449441at2759; -.
DR PhylomeDB; Q8N945; -.
DR TreeFam; TF337953; -.
DR PathwayCommons; Q8N945; -.
DR BioGRID-ORCS; 153768; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; PRELID2; human.
DR GenomeRNAi; 153768; -.
DR Pharos; Q8N945; Tdark.
DR PRO; PR:Q8N945; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N945; protein.
DR Bgee; ENSG00000186314; Expressed in oocyte and 142 other tissues.
DR ExpressionAtlas; Q8N945; baseline and differential.
DR Genevisible; Q8N945; HS.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..189
FT /note="PRELI domain-containing protein 2"
FT /id="PRO_0000307773"
FT DOMAIN 1..187
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT VAR_SEQ 1..29
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028824"
FT VAR_SEQ 69..80
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044841"
FT VAR_SEQ 70..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028825"
FT VARIANT 99
FT /note="N -> S (in dbSNP:rs9324996)"
FT /id="VAR_053910"
SQ SEQUENCE 189 AA; 21905 MW; AE39CE8FE26C7851 CRC64;
MGVSVDVHQV YKYPFEQVVA SFLRKYPNPM DKNVISVKIM EEKRDESTGV IYRKRIAICQ
NVVPEILRKS LSTLVILCWK KVSILKVPNI QLEEESWLNP RERNMAIRSH CLTWTQYASM
KEESVFRESM ENPNWTEFIQ RGRISITGVG FLNCVLETFA STFLRQGAQK GIRIMEMLLK
EQCGAPLAE
