ID   PRLF_FUNXX              Reviewed;         494 AA.
AC   A0A089GT84;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Pyrrolocin cluster transcription factor fsdR {ECO:0000303|PubMed:25226362};
DE   AltName: Full=Pyrrolocin biosynthesis protein R {ECO:0000303|PubMed:25226362};
GN   Name=prlF {ECO:0000303|PubMed:25226362};
OS   Fungal sp. (strain NRRL 50135).
OC   Eukaryota; Fungi.
OX   NCBI_TaxID=1547289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=25226362; DOI=10.1021/sb500296p;
RA   Kakule T.B., Jadulco R.C., Koch M., Janso J.E., Barrows L.R., Schmidt E.W.;
RT   "Native promoter strategy for high-yielding synthesis and engineering of
RT   fungal secondary metabolites.";
RL   ACS Synth. Biol. 4:625-633(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of pyrrolocin
CC       (PubMed:25226362). {ECO:0000305|PubMed:25226362}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; KM107910; AIP87506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A089GT84; -.
DR   SMR; A0A089GT84; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..494
FT                   /note="Pyrrolocin cluster transcription factor fsdR"
FT                   /id="PRO_0000441308"
FT   DNA_BIND        17..49
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          57..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  52739 MW;  353AC921A98052FD CRC64;
     MALSPSSDAI LSIRSSCDRC RSQKLKCIVI ETPSGTACCQ RCARAMVPCI FGRRSRSKRT
     TTTTTTTTTD SGRKQRRREP AAALNVLDSC AAPELAASSS STNAHFPRGI NGGMGIPEDR
     ENQETGTFPF YAGCYGGSAP VTSAVEVIQG RKDPDRNLFR YAFQEESTIG DLGLFTHDMS
     LFGQTLDDAS LANTEVMPPS LTESDGISSP GESAPFRVHL PLSEPGVAAR VLLSFASDLH
     ERLETLQNGP WQQEESSMGL DGYPIGSVLH LSLTLTDLGV ALQKARSNDD ASVSASSHKM
     DDGQTERVNP NSTQAGGIST STTTEPPCYD TSVSLMLLSC YVTLLRVCTV VLGNFQTYLH
     LQPRARPKAS PASIYPSSAS CLGDLLPINQ PHHRIHAAVC LLLDSLEQVE EALSLPYQVR
     CASAVQASSD PGSCTPSEAK PFSDAPAGAA GRDSATTLIH WGFQTSAAGM QDASSELRQK
     VEGVKEMLRQ QMGL