ID   PRLG_FUNXX              Reviewed;         473 AA.
AC   A0A089FRP6;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=MFS transporter prlG {ECO:0000303|PubMed:25226362};
DE   AltName: Full=Pyrrolocin biosynthesis protein G {ECO:0000303|PubMed:25226362};
GN   Name=prlG {ECO:0000303|PubMed:25226362};
OS   Fungal sp. (strain NRRL 50135).
OC   Eukaryota; Fungi.
OX   NCBI_TaxID=1547289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=25226362; DOI=10.1021/sb500296p;
RA   Kakule T.B., Jadulco R.C., Koch M., Janso J.E., Barrows L.R., Schmidt E.W.;
RT   "Native promoter strategy for high-yielding synthesis and engineering of
RT   fungal secondary metabolites.";
RL   ACS Synth. Biol. 4:625-633(2015).
CC   -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC       pyrrolocin or other secondary metabolies produced by the pyrrolocin
CC       gene cluster (PubMed:25226362). {ECO:0000305|PubMed:25226362}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; KM107910; AIP87507.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A089FRP6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..473
FT                   /note="MFS transporter prlG"
FT                   /id="PRO_0000441312"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  51360 MW;  07C24AFADEF0E228 CRC64;
     MSSTDAEAKN EEAVDWEGPD DPENPRNWNQ GAKMTHVLLV SSFTLYSNLA AVMFAPGAQD
     LVAEFGITST IVASLTVSIY ILGYVFGPFL LASMSEIYGR LIIYHICNAV YIAFTIGCAL
     STDTAMFLVF RFICGCAASA PMAIGGGTIA DLHKPEERGK AMALFGLGPL LGPVIGPVVG
     GFVTQFLGWR WTFWLVLILA GVVSLLALVL MRETFEPVLL TRKAAELRKS TGNYRLQART
     YNKDLTPAQL LARATIRPTK MLLMSPIVFL LSVYCAFMFG LTYLLFTTFP AVFEETYGFA
     ADVSGLAYLG LGVGMIISIG LFAVLSDKLL HQPHGGTIAR PELRLILMIW SSPLVPIGFF
     WYGWSAKYEV HWIVPILGTS VIGLGAFLIL MPAQLYLVDA FGTEAAASAL AANTVLRSLF
     GAVLPLAGPS LYDSLGLGWG NSLLAFIGLA FAPVPFFFYK YGERLRVRFP VNS