PRLHR_BOVIN
ID PRLHR_BOVIN Reviewed; 370 AA.
AC Q4EW11;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Prolactin-releasing peptide receptor;
DE Short=PrRP receptor;
DE Short=PrRPR;
DE AltName: Full=G-protein coupled receptor 10;
GN Name=PRLHR; Synonyms=GPR10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Pituitary;
RA Feng H., Yuan Z., Xiao S.D., Ying Y., Chun W.Y.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for prolactin-releasing peptide (PrRP). Implicated
CC in lactation, regulation of food intake and pain-signal processing (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts through its C-terminal region with the PDZ domain-
CC containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains
CC 4 and 5 of GRIP1 and with the PDZ domain of PICK1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; DQ119288; AAZ09449.1; -; Genomic_DNA.
DR RefSeq; NP_001025471.1; NM_001030300.1.
DR RefSeq; XP_015316236.1; XM_015460750.1.
DR AlphaFoldDB; Q4EW11; -.
DR SMR; Q4EW11; -.
DR STRING; 9913.ENSBTAP00000055441; -.
DR PaxDb; Q4EW11; -.
DR Ensembl; ENSBTAT00000065752; ENSBTAP00000055441; ENSBTAG00000047842.
DR GeneID; 510397; -.
DR KEGG; bta:510397; -.
DR CTD; 2834; -.
DR VEuPathDB; HostDB:ENSBTAG00000047842; -.
DR VGNC; VGNC:33345; PRLHR.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162008; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q4EW11; -.
DR OMA; LAWPRKI; -.
DR OrthoDB; 1072979at2759; -.
DR TreeFam; TF315303; -.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000047842; Expressed in oviduct epithelium and 4 other tissues.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0042445; P:hormone metabolic process; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001402; Prolrel_pep_rcpt.
DR PANTHER; PTHR24235:SF11; PTHR24235:SF11; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01018; PRPRECEPTOR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..370
FT /note="Prolactin-releasing peptide receptor"
FT /id="PRO_0000069523"
FT TOPO_DOM 1..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 365..370
FT /note="Required for interaction with GRIP1, GRIP2 and
FT PICK1"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 370 AA; 41226 MW; 5E4580C74236D475 CRC64;
MASLPTQGPA APDFFNGLLP ASSSPVNQSS ETVVGNGSAA GPGSQAITPF QSLQLVHQLK
GLIVLLYSIV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC TACVPLTLAY
AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLRFSAYAV
LAIWALSAVL ALPAALHTYH VELKPHRVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV
ILLSYVRVSV NLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVVVVVFAVC WLPLHVFNLL
RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL LAWPRKIAPH
GQSMTVSVVI
