ID   PRLL_FUNXX              Reviewed;         495 AA.
AC   A0A089FNE5;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=MFS transporter prlL {ECO:0000303|PubMed:25226362};
DE   AltName: Full=Pyrrolocin biosynthesis protein L {ECO:0000303|PubMed:25226362};
GN   Name=prlL {ECO:0000303|PubMed:25226362};
OS   Fungal sp. (strain NRRL 50135).
OC   Eukaryota; Fungi.
OX   NCBI_TaxID=1547289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=25226362; DOI=10.1021/sb500296p;
RA   Kakule T.B., Jadulco R.C., Koch M., Janso J.E., Barrows L.R., Schmidt E.W.;
RT   "Native promoter strategy for high-yielding synthesis and engineering of
RT   fungal secondary metabolites.";
RL   ACS Synth. Biol. 4:625-633(2015).
CC   -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC       pyrrolocin or other secondary metabolies produced by the pyrrolocin
CC       gene cluster (PubMed:25226362). {ECO:0000305|PubMed:25226362}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; KM107910; AIP87508.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A089FNE5; -.
DR   SMR; A0A089FNE5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..495
FT                   /note="MFS transporter prlL"
FT                   /id="PRO_0000441313"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   495 AA;  54249 MW;  ABDF58EF3A98CFC0 CRC64;
     MAQSFANEHD PAKRAEERGH VGTIEDVESG TKEPYIAEEP ISAEAARALI WKQDKRIIPL
     SAAIYFLCYL DRSNIGNAKI LNAATGNDLL TETHMTNYDY TIALMIFFLA YGLFEVPSNV
     LLKKLHPSRW IAILMFSWGA ISMGLAGAHN YATVTVVRFL LGIFEAGLFP GLVYYLTFWY
     KTEERSIRVA FILASATLAG AFGGAIAYAV GHMNQAHGIS AWRWLFIIEG APSCVSALFV
     LFFLPDYPET VNWLSDEERE LALRRLRVEG SKGLHQSDWW KDAKSTLVEW RLWAHYLIYF
     GISTPFSSLS LFTPSITAGL GYDGLQAQLM TVPPYAVAYV VQILVSWSAD RTNSRGLHSA
     ASATVGACGF LASAVLPAEA YLHRYGCLIV AAAGAFACIP PLLGWLSSNI FSTASVGLAI
     ALNIGLGGAP GQIAGVWIYK ADEAKKGYPT GHWVNAGLLF FVAVACVALR LHYGFRNRKT
     VRETGGIEGV RLFKY