ID   PRLR_FUNXX              Reviewed;         772 AA.
AC   A0A089FQI6;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Pyrrolocin cluster transcription factor fsdR {ECO:0000303|PubMed:25226362};
DE   AltName: Full=Pyrrolocin biosynthesis protein R {ECO:0000303|PubMed:25226362};
GN   Name=prlR {ECO:0000303|PubMed:25226362};
OS   Fungal sp. (strain NRRL 50135).
OC   Eukaryota; Fungi.
OX   NCBI_TaxID=1547289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=25226362; DOI=10.1021/sb500296p;
RA   Kakule T.B., Jadulco R.C., Koch M., Janso J.E., Barrows L.R., Schmidt E.W.;
RT   "Native promoter strategy for high-yielding synthesis and engineering of
RT   fungal secondary metabolites.";
RL   ACS Synth. Biol. 4:625-633(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of pyrrolocin
CC       (PubMed:25226362). {ECO:0000305|PubMed:25226362}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KM107910; AIP87509.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A089FQI6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..772
FT                   /note="Pyrrolocin cluster transcription factor fsdR"
FT                   /id="PRO_0000441307"
FT   DNA_BIND        46..74
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  85578 MW;  F3FB706B995B8346 CRC64;
     MSDAVTPCSS AKVPSVQEFI TTSSDTQTDR PRPPLSRRRD KPQLSCNACR RRKVRCDRLH
     PCSNCSSRGH GSSCEYAPTT PTTGTAASTI TEKPPLPGPL HGTASNMQNR IDQLESLVLG
     LMHQHQTGPS SRASPLEEPP PRPITPDQRA ASPSVTGSDR ILTFAPETQR DVSPTPSDYG
     SIRIQQTGVS YVSSSHWAAI LGSIADLRSH FAQEDEAHSR SASHVQPPTA FPKPQLLYSS
     LVNETPASIV KSVPPRPVVD RLLSRYFNVL DIAPAYVRQQ YEEFWKAPHA APIMWVGLLF
     SMMCLSTQLQ QALLGLNKPS PTLGHSRRPS QAAESQETVE SYKEKAIQCL ILGHYTKGGP
     YVLETLILYF LVECFHLKDM EVGVWMLVGN IVQVAILMGY HRDADHFPNI SPFAGEMRRR
     VWAMIVQLDF SISTQLGLPR LVKESQTDTA EPRNLHDSDF DELTTELPTS RPETEVTPTL
     YVLAKLRLLS VGVKVADVAT EPRPHSYAEV LELDHQINEA RSALPSSLKW SGLGSSLNVP
     SQIIIQRIWL EVIAQQLKIV LHRKFLEPSR LQQHYGSSRS ACLTAAMKIL QLQRLVDEET
     QADGLLYQSR WRVSSAFIND FLLATSILCF CLQSHADEQK DTNRTSKDAE AAPVDIEEIR
     QLLNTSLVIW SRQCASSREA RRAVAALRYV LGDSGIRSEP HPSEDVLSAP VPAAAISYFP
     GFSDLMTEYD LPSLGLEPTI EGTTWPVFTT NLNNNIDHWA GVTGFQQMDL SS