ID   PRL_AILME               Reviewed;         229 AA.
AC   Q8HXS1;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15493147;
RA   Zheng X., Zhang Z.H., Hu X.L., Liao M.J., Zhang A.J., Zhu M.Y.;
RT   "Cloning and expression of pituitary prolactin gene in Ailuropoda
RT   melanoleuca.";
RL   Yi Chuan Xue Bao 31:963-969(2004).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AY161285; AAN78320.1; -; mRNA.
DR   RefSeq; NP_001291863.1; NM_001304934.1.
DR   AlphaFoldDB; Q8HXS1; -.
DR   SMR; Q8HXS1; -.
DR   STRING; 9646.ENSAMEP00000011769; -.
DR   Ensembl; ENSAMET00000031918; ENSAMEP00000026858; ENSAMEG00000011161.
DR   GeneID; 100481524; -.
DR   KEGG; aml:100481524; -.
DR   CTD; 5617; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; Q8HXS1; -.
DR   OMA; NEVYSRW; -.
DR   OrthoDB; 1290070at2759; -.
DR   TreeFam; TF332592; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000250"
FT   CHAIN           31..229
FT                   /note="Prolactin"
FT                   /id="PRO_0000032910"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         120
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        34..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  26236 MW;  441E3D748CFDDBC2 CRC64;
     MDKKGWSLKG SLLPLLLLVS DLLLCQSVAS LPICPTGAVN CQVSLRDLFD RAVILSHYIH
     NLSSEMFNEF DKRYAQGRGF ITKAINSCHT SSLSTPEDKE QAQQIHHEDL LNLILRVLRS
     WNDPLYHLVT EVRGMQEAPD SILSRAIEIE EQNRRLLEGM EKIVGQVHPG VRENEVYSVW
     SGLPSLQMAD EDTRLFAFYN LLHCLRRDSH KIDNYLKLLK CRIVYDSNC