ID   PRL_ANGAN               Reviewed;         209 AA.
AC   P33096;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7926267; DOI=10.1016/0303-7207(94)90108-2;
RA   Querat B., Cardinaud B., Hardy A., Vidal B., D'Angelo G.;
RT   "Sequence and regulation of European eel prolactin mRNA.";
RL   Mol. Cell. Endocrinol. 102:151-160(1994).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X69149; CAA48902.1; -; mRNA.
DR   PIR; I49983; S30541.
DR   AlphaFoldDB; P33096; -.
DR   SMR; P33096; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..209
FT                   /note="Prolactin"
FT                   /id="PRO_0000032930"
FT   DISULFID        70..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..209
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   209 AA;  23115 MW;  FC7B6FBB67C79BB0 CRC64;
     MAQRFKGRSL FLTALLCLAS QGYAVGLGDM LERASQLSDK LHSLSTSLTN DLDTHFPPMG
     KILMPRPSMC HTASLQTPHD KDQALRVPES ELLSIARALL LSWNDPLLLL ASEAPTLSHP
     QNGAIYSKTR ELQDQSNSLS SGLDRLIHKI GSSSKALSPL PLQGGDLGSD KNSRLINFYF
     LLSCFRRDSH KIDNFLKLLR CRAAKQDRC