ID   PRL_ANGJA               Reviewed;         209 AA.
AC   Q7ZZV3;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Anguilla japonica (Japanese eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Han Y.-S., Yu J.Y.-L., Liao I.-C., Tzeng W.-N.;
RT   "Salinity preference of the silvering Japanese eel Anguilla japonica:
RT   evidences from the pituitary prolactin mRNA levels and otolith
RT   strontium/calcium ratios.";
RL   Mar. Ecol. Prog. Ser. 259:253-261(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AY158009; AAO17792.1; -; mRNA.
DR   AlphaFoldDB; Q7ZZV3; -.
DR   SMR; Q7ZZV3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..209
FT                   /note="Prolactin"
FT                   /id="PRO_0000032931"
FT   DISULFID        70..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..209
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   209 AA;  23155 MW;  346A9EBE10C3F467 CRC64;
     MAQRFKGSNL FLTALLCLAS QGHAVGLGDM LERASQLSDK LHSLSTSLTN DLDTHFPPMG
     KILMPRPSMC HTASLQTPHD KDQALRVPES ELLSLARALL LSWNDPLLLL TSEAPTLSHP
     QNGVIYSKTR ELQDQSNSLS SGLDRLIHKI GSSSKSLSPL PFQGGDLGSD KNSRLINFYF
     LLSCFRRDSH KIDNFLKLLR CRAAKQDRC