ID   PRL_BALBO               Reviewed;         199 AA.
AC   P33089;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
GN   Name=PRL;
OS   Balaenoptera borealis (Sei whale) (Pollack whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9768;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4052510;
RA   Karaseva L.I., Pankov Y.A.;
RT   "Primary structure of whale prolactin.";
RL   Biokhimiia 50:1528-1534(1985).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; PN0128; PN0128.
DR   AlphaFoldDB; P33089; -.
DR   SMR; P33089; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Lactation;
KW   Phosphoprotein; Secreted.
FT   CHAIN           1..199
FT                   /note="Prolactin"
FT                   /id="PRO_0000181317"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        4..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..174
FT                   /evidence="ECO:0000250"
FT   DISULFID        191..199
FT                   /evidence="ECO:0000250"
FT   UNSURE          74
FT                   /note="Q or E"
FT   UNSURE          93
FT                   /note="D or N"
SQ   SEQUENCE   199 AA;  22812 MW;  4098AFC9BFD98BA4 CRC64;
     LPICPSGAVN CQVSLRDLFD RAVILSHYIH NLSSEMFNEF DKRYAQGRGF ITKAIDSCHT
     SSLQTPEDKE QAQQIHHEVL VSLILGVLRS WNDPLYHLVT EVRGMQEAPD AILSRAIQIE
     EENKRLLEGM EKIVGQVHPG VKENEVYSVW SGLPSLQMAD EDTRLFAFYD LLHCLRRDSH
     KIDSYLKLLK CRIIYNSNC