ID   ATG16_VANPO             Reviewed;         123 AA.
AC   A7TIN2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Autophagy-related protein 16;
GN   Name=ATG16; ORFNames=Kpol_1043p14;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Stabilizes the ATG5-ATG12 conjugate which is necessary for
CC       autophagy. The ATG5-ATG12/ATG16 complex is required for efficient
CC       promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8
CC       localization to the pre-autophagosomal structure (PAS). Recruits also
CC       ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic
CC       process and is essential for the survival of cells subjected to severe
CC       ER stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16
CC       complex. Several units of each may be present in this complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q03818}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03818}.
CC   -!- SIMILARITY: Belongs to the ATG16 family. {ECO:0000305}.
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DR   EMBL; DS480397; EDO17824.1; -; Genomic_DNA.
DR   RefSeq; XP_001645682.1; XM_001645632.1.
DR   AlphaFoldDB; A7TIN2; -.
DR   SMR; A7TIN2; -.
DR   STRING; 436907.A7TIN2; -.
DR   PRIDE; A7TIN2; -.
DR   EnsemblFungi; EDO17824; EDO17824; Kpol_1043p14.
DR   GeneID; 5546078; -.
DR   KEGG; vpo:Kpol_1043p14; -.
DR   eggNOG; ENOG502S6TV; Eukaryota.
DR   HOGENOM; CLU_158825_0_0_1; -.
DR   InParanoid; A7TIN2; -.
DR   OMA; QLRNKDY; -.
DR   OrthoDB; 1616621at2759; -.
DR   PhylomeDB; A7TIN2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR   Pfam; PF08614; ATG16; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..123
FT                   /note="Autophagy-related protein 16"
FT                   /id="PRO_0000317977"
FT   COILED          57..106
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   123 AA;  14616 MW;  6D59E753967F0F3E CRC64;
     MDSLFVERLA QRDEVEGRFC ELFKEVQIMV GPQLEDESME RKLIVALKSD LVEKDLRIGE
     LEEILQLRNK DYERLNDELI SLNIENNILR DKLQNMTEEN SKLVKRWLNK VQQEADAMNE
     NLH