ID   PRL_BUFJA               Reviewed;         134 AA.
AC   P43001;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Fragment;
OS   Bufo japonicus (Japanese toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo.
OX   NCBI_TaxID=8387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8148042; DOI=10.1677/jme.0.0110343;
RA   Takahashi N., Yamamoto K., Kikuyama S.;
RT   "Cloning of a toad prolactin cDNA: expression of prolactin mRNA in larval
RT   and adult pituitaries.";
RL   J. Mol. Endocrinol. 11:343-349(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S69309; AAB30425.1; -; mRNA.
DR   PIR; I51233; I51233.
DR   AlphaFoldDB; P43001; -.
DR   SMR; P43001; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted.
FT   CHAIN           <1..134
FT                   /note="Prolactin"
FT                   /id="PRO_0000181320"
FT   DISULFID        126..134
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   134 AA;  15520 MW;  D0C7BD7A26DB5544 CRC64;
     PEDKEQAQQI QHEDLLSLVL KVLRSWNDPL LHMVSEVQDI QEAPDTILWK AVEIEEQTKR
     LLEGMERIVG RIHPGDLENE IYSPWPGPSA AIPGDESSRL FAFYNLLHCL RRDSHKIDNY
     LKLLKCRLIH DGNC