ID   PRL_CAPHI               Reviewed;         229 AA.
AC   Q28318; Q28329;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7969789; DOI=10.1159/000126763;
RA   le Provost F., Leroux C., Martin P., Gaye P., Djiane J.;
RT   "Prolactin gene expression in ovine and caprine mammary gland.";
RL   Neuroendocrinology 60:305-313(1994).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X76049; CAA53634.1; -; mRNA.
DR   EMBL; X76048; CAA53633.1; -; mRNA.
DR   PIR; I83982; I83982.
DR   RefSeq; NP_001272476.1; NM_001285547.1.
DR   AlphaFoldDB; Q28318; -.
DR   SMR; Q28318; -.
DR   GeneID; 100861193; -.
DR   KEGG; chx:100861193; -.
DR   CTD; 100861193; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; ISS:AgBase.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR   GO; GO:0030072; P:peptide hormone secretion; ISS:AgBase.
DR   GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000250"
FT   CHAIN           31..229
FT                   /note="Prolactin"
FT                   /id="PRO_0000032912"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         120
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        34..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
FT   VARIANT         164
FT                   /note="L -> F"
SQ   SEQUENCE   229 AA;  25774 MW;  331C640C66134D0A CRC64;
     MDSKGSAQKG SRLLLLLVVS NLLLCQGVVS TPVCPNGPGN CQVSLRDLFD RAVMVSHYIH
     NLSSEMFNEF DKRYAQGKGY ITMALNSCHT SSLPTPEDKE QAQQTHHEVL MSLILGLLRS
     WNDPLYHLVT EVRGMKGVPD AILSRAIEIE EENKRLLEGM EMILGQVIPG AKETEPYPVW
     SGLPSLQTKD EEARHSAFYN LLHCLRRDSS KIDTYLKLLN CRIIYNNNC