ID   PRL_CHEMY               Reviewed;         198 AA.
AC   P33090;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BONDS.
RX   PubMed=2289679; DOI=10.1016/0016-6480(90)90185-o;
RA   Yasuda A., Kawauchi H., Papkoff H.;
RT   "The complete amino acid sequence of prolactin from the sea turtle
RT   (Chelonia mydas).";
RL   Gen. Comp. Endocrinol. 80:363-371(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; A60620; A60620.
DR   AlphaFoldDB; P33090; -.
DR   SMR; P33090; -.
DR   STRING; 8469.XP_007059983.1; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   CHAIN           1..198
FT                   /note="Prolactin"
FT                   /id="PRO_0000181323"
FT   DISULFID        4..11
FT                   /evidence="ECO:0000269|PubMed:2289679"
FT   DISULFID        58..173
FT                   /evidence="ECO:0000269|PubMed:2289679"
FT   DISULFID        190..198
FT                   /evidence="ECO:0000269|PubMed:2289679"
FT   VARIANT         55
FT                   /note="I -> L"
FT   VARIANT         145
FT                   /note="L -> V"
FT   VARIANT         148
FT                   /note="P -> R"
FT   VARIANT         171
FT                   /note="L -> M"
SQ   SEQUENCE   198 AA;  22606 MW;  8AC5B1600272053D CRC64;
     LPICPSGSVG CQVSLENLFD RAVKLSHYIH SLSSEMFNEF DERYAQGRGF LTKAINGCHT
     SSLTTPEDKE QAQQIHHEDL LNLVLGVLRS WNDPLLHLVS EVQSIKEAPD TILKAVEIEE
     QDKRLLEGME KIVGQVHPGE IENELYSPWS GLPSLQQVDE DSRLFAFYNL LHCLRRDSHK
     IDNYLKLLKC RLIHDNDC