PRL_CHICK
ID PRL_CHICK Reviewed; 229 AA.
AC P14676; Q66XJ8; Q90ZB1; Q9DEI3;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Prolactin;
DE Short=PRL;
DE Flags: Precursor;
GN Name=PRL;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2925618; DOI=10.1016/s0021-9258(18)83578-5;
RA Watahiki M., Yamamoto M., Yamakawa M., Tanaka M., Nakashima K.;
RT "Primary structure of chicken pituitary prolactin deduced from the cDNA
RT sequence. Conserved and specific amino acid residues in the domains of the
RT prolactins.";
RL J. Biol. Chem. 264:5535-5539(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2765112; DOI=10.1677/jme.0.0020021;
RA Hanks M.C., Alonzi J.A., Sharp P.J., Sang H.M.;
RT "Molecular cloning and sequence analysis of putative chicken prolactin
RT cDNA.";
RL J. Mol. Endocrinol. 2:21-30(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ohkubo T., Tanaka M., Nakashima K.;
RT "Cloning and characterization of chicken prolactin gene.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Au W.L., Leung F.C.;
RT "Genomic sequence of chicken prolactin gene.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=15843347;
RA Cui J.X., Du H.L., Zhang X.Q.;
RT "Polymorphisms and bioinformatics analysis of chicken prolactin gene.";
RL Yi Chuan 27:208-214(2005).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; J04614; AAA49040.1; -; mRNA.
DR EMBL; AB011438; BAB18728.1; -; Genomic_DNA.
DR EMBL; AF288765; AAG01026.1; -; Genomic_DNA.
DR EMBL; AY588297; AAT02222.1; -; Genomic_DNA.
DR EMBL; AY588296; AAT02222.1; JOINED; Genomic_DNA.
DR EMBL; AY588295; AAT02222.1; JOINED; Genomic_DNA.
DR EMBL; AY588294; AAT02222.1; JOINED; Genomic_DNA.
DR EMBL; AY588304; AAT02223.1; -; Genomic_DNA.
DR EMBL; AY588301; AAT02223.1; JOINED; Genomic_DNA.
DR EMBL; AY588302; AAT02223.1; JOINED; Genomic_DNA.
DR EMBL; AY588303; AAT02223.1; JOINED; Genomic_DNA.
DR EMBL; AY588311; AAT02224.1; -; Genomic_DNA.
DR EMBL; AY588308; AAT02224.1; JOINED; Genomic_DNA.
DR EMBL; AY588309; AAT02224.1; JOINED; Genomic_DNA.
DR EMBL; AY588310; AAT02224.1; JOINED; Genomic_DNA.
DR EMBL; AY588318; AAT02225.1; -; Genomic_DNA.
DR EMBL; AY588316; AAT02225.1; JOINED; Genomic_DNA.
DR EMBL; AY588317; AAT02225.1; JOINED; Genomic_DNA.
DR EMBL; AY588315; AAT02225.1; JOINED; Genomic_DNA.
DR PIR; A60972; A60972.
DR RefSeq; NP_990797.2; NM_205466.2.
DR AlphaFoldDB; P14676; -.
DR SMR; P14676; -.
DR STRING; 9031.ENSGALP00000020651; -.
DR PaxDb; P14676; -.
DR Ensembl; ENSGALT00000020680; ENSGALP00000020651; ENSGALG00000012671.
DR GeneID; 396453; -.
DR KEGG; gga:396453; -.
DR CTD; 5617; -.
DR VEuPathDB; HostDB:geneid_396453; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; P14676; -.
DR OMA; NEVYSRW; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; P14676; -.
DR TreeFam; TF332592; -.
DR PRO; PR:P14676; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000012671; Expressed in brain and 1 other tissue.
DR ExpressionAtlas; P14676; baseline.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; TAS:AgBase.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT CHAIN 31..229
FT /note="Prolactin"
FT /id="PRO_0000032928"
FT DISULFID 34..41
FT /evidence="ECO:0000250"
FT DISULFID 88..204
FT /evidence="ECO:0000250"
FT DISULFID 221..229
FT /evidence="ECO:0000250"
FT CONFLICT 171
FT /note="D -> H (in Ref. 1 and 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="W -> S (in Ref. 1 and 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="L -> H (in Ref. 1 and 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 25863 MW; 11314FEF65F775AE CRC64;
MSNRGASLKG LFLAVLLVSN TLLTKEGVTS LPICPIGSVN CQVSLGELFD RAVKLSHYIH
YLSSEIFNEF DERYAQGRGF ITKAVNGCHT SSLTTPEDKE QAQQIHHEDL LNLVVGVLRS
WNDPLIHLAS EVQRIKEAPD TILWKAVEIE EQNKRLLEGM EKIVGRVHSG DAGNEIYSHW
DGLPSLQLAD EDSRLFAFYN LLHCLRRDSH KIDNYLKVLK CRLIHDSNC
