PRL_CYPCA
ID PRL_CYPCA Reviewed; 210 AA.
AC P09585;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Prolactin;
DE Short=PRL;
DE Flags: Precursor;
GN Name=prl;
OS Cyprinus carpio (Common carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=3174460; DOI=10.1093/nar/16.19.9350;
RA Chao S.-C., Pan F.-M., Chang W.-C.;
RT "Nucleotide sequence of carp prolactin cDNA.";
RL Nucleic Acids Res. 16:9350-9350(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2001405; DOI=10.1016/0167-4781(91)90071-s;
RA Chen H.T., Chiou C.S., Chang W.-C.;
RT "Cloning and characterization of the carp prolactin gene.";
RL Biochim. Biophys. Acta 1088:315-318(1991).
RN [3]
RP PROTEIN SEQUENCE OF 24-210.
RC TISSUE=Pituitary;
RX PubMed=3582956; DOI=10.1016/0016-6480(87)90278-4;
RA Yasuda A., Miyazama K., Kawauchi H., Peter R.E., Lin H.-R., Yamaguchi K.,
RA Sano H.;
RT "Primary structure of common carp prolactins.";
RL Gen. Comp. Endocrinol. 66:280-290(1987).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: The sequence shown is that of prolactin II.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; X12543; CAA31060.1; -; mRNA.
DR EMBL; X52881; CAA37063.1; -; Genomic_DNA.
DR PIR; S01435; S01435.
DR AlphaFoldDB; P09585; -.
DR SMR; P09585; -.
DR Ensembl; ENSCCRT00010040554; ENSCCRP00010036932; ENSCCRG00010015760.
DR Ensembl; ENSCCRT00020024133; ENSCCRP00020021971; ENSCCRG00020010274.
DR Proteomes; UP000694384; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:3582956"
FT CHAIN 24..210
FT /note="Prolactin"
FT /id="PRO_0000032934"
FT DISULFID 69..183
FT DISULFID 200..210
FT VARIANT 90
FT /note="E -> P (in prolactin-1)"
FT CONFLICT 35
FT /note="Q -> E (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="I -> V (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="I -> V (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="D -> E (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="Q -> N (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 150..152
FT /note="GSS -> DST (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="S -> N (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="Q -> E (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="Missing (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 23297 MW; 3743AC1F9ADDCCA6 CRC64;
MTQGSRLYFA VTVLMCAFVS INGVGLNDLL ERASQLSDKL HSLSTSLTND LDSHFPPVGR
VMMPRPSMCH TSSLQIPNDK DQALKIPEDE LLSLARSLLL AWSDPLALLS SEASSLAHPE
RNTIDSKTKE LQDNINSLGA GLEHVFQKMG SSSDNLSSLP FYTSSLGQDK TSRLVNFHFL
LSCFRRDSHK IDSFLKVLRC RAAKKRPEMC
