ID   PRL_DICLA               Reviewed;         212 AA.
AC   P48249;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Dicentrarchus labrax (European seabass) (Morone labrax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Dicentrarchus.
OX   NCBI_TaxID=13489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7804137;
RA   Doliana R., Argentini C., Segat D., Santarossa P., Mucignat M.T.,
RA   Colombo L., Bortolussi M.;
RT   "The prolactin of European sea bass (Dicentrarchus labrax L.): cloning of
RT   cDNA and efficient expression in Escherichia coli.";
RL   Biochem. Mol. Biol. Int. 33:1117-1126(1994).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X78723; CAA55369.1; -; mRNA.
DR   PIR; I51275; I51275.
DR   AlphaFoldDB; P48249; -.
DR   SMR; P48249; -.
DR   PRIDE; P48249; -.
DR   Proteomes; UP000694389; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..212
FT                   /note="Prolactin"
FT                   /id="PRO_0000032935"
FT   DISULFID        70..185
FT                   /evidence="ECO:0000250"
FT   DISULFID        202..212
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   212 AA;  23489 MW;  2CB4D2EE0D793F9F CRC64;
     MAQRKTNGSK LFMMVLYMVA ACSAIPISDL LDRASQRSDT LHSLSTTLTQ DLDSHFPPMG
     RVITPRPSMC HTSSLHTPID KEQALQVSEA DLLSLVRSLL QAWRDPLVIL STSANTLPHP
     AQNSISTKVQ ELLEHTKSLG DGLDILSGKF GPAAQSISSL PYRGGNDISQ DRISRLTNFH
     FLMSCFRRDS HKIDSFLKVL RCRAAKLQPE MC