ID   PRL_HYPMO               Reviewed;         207 AA.
AC   P35395;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor; Fragment;
GN   Name=prl;
OS   Hypophthalmichthys molitrix (Silver carp) (Leuciscus molitrix).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Hypophthalmichthys.
OX   NCBI_TaxID=13095;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=1398019; DOI=10.1016/0016-6480(92)90030-n;
RA   Chang Y.S., Huang F.-L., Lo T.B.;
RT   "Molecular cloning of silver carp and bighead carp prolactin.";
RL   Gen. Comp. Endocrinol. 87:260-265(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X61052; CAA43386.1; -; mRNA.
DR   PIR; S21965; S21965.
DR   AlphaFoldDB; P35395; -.
DR   SMR; P35395; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          <1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..207
FT                   /note="Prolactin"
FT                   /id="PRO_0000032936"
FT   DISULFID        66..180
FT                   /evidence="ECO:0000250"
FT   DISULFID        197..207
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   207 AA;  23034 MW;  E8302AA6855FC64D CRC64;
     KSRLYFAVTV LMCAFVSING VGLNDLLERA SQLSDKLHSL STSLTNDLDS HFPPVGRVMM
     PRPSMCHTSS LQIPNDKDQA LKVPEDELLS LARSLLLAWS DPLALLSSKA SSLAHPERNT
     INSKTKELQD NINSLVPGLE HVVHKMGSSS DNLSSLPFYS NSLGQDKTSR LVNFHFLLSC
     FRRDSHKIDS FLKVLRCRAA KKRPEMC