ID   PRL_ICTPU               Reviewed;         212 AA.
AC   P51904; Q9I819;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Pituitary;
RA   Tang Y.;
RT   "A study on the channel catfish (Ictalurus punctatus) growth hormone gene
RT   family: structures of growth hormone and prolactin genes and somatolactin
RT   cDNA, their evolutionary implications and expression in the pituitary
RT   gland.";
RL   Thesis (1993), University of Maryland, United States.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-212.
RC   TISSUE=Pituitary;
RX   PubMed=1308206;
RA   Watanabe K., Igarashi A., Noso T., Chen T.T., Dunham R.A., Kawauchi H.;
RT   "Chemical identification of catfish growth hormone and prolactin.";
RL   Mol. Mar. Biol. Biotechnol. 1:239-249(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF267990; AAF82287.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51904; -.
DR   SMR; P51904; -.
DR   STRING; 7998.ENSIPUP00000009385; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..26
FT   CHAIN           27..212
FT                   /note="Prolactin"
FT                   /id="PRO_0000032938"
FT   DISULFID        71..185
FT                   /evidence="ECO:0000250"
FT   DISULFID        202..212
FT                   /evidence="ECO:0000250"
FT   CONFLICT        91
FT                   /note="G -> S (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        128
FT                   /note="T -> S (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        203
FT                   /note="D -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   212 AA;  23366 MW;  073FB7FB1DA573BE CRC64;
     MARCCKCPRL HLAVTVLACV LVFTEGVNLN DLLDRASQLS DKMHSLSTSL TNDLDSHFSS
     VGGKLMRPSM CHTSSLQIPN DKDQALSVPE GELLSLVRSL LMAWSDPLAL LSSEATSLPH
     PERNSINTKT RELQDHTNSL GAGLERLGRK MGSSPESLSS LPFNSNDLGQ DNISRLVNFH
     FLLSCFRRDS HKIDSFLKVL RCDAAKMLPE MC