ID   PRL_LOXAF               Reviewed;         199 AA.
AC   P10765;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
GN   Name=PRL;
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2722400; DOI=10.1111/j.1399-3011.1989.tb00684.x;
RA   Li C.H., Oosthuizen M.M.J., Chung D.;
RT   "Primary structure of elephant pituitary prolactin.";
RL   Int. J. Pept. Protein Res. 33:67-69(1989).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P10765; -.
DR   SMR; P10765; -.
DR   STRING; 9785.ENSLAFP00000016822; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; P10765; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Lactation;
KW   Phosphoprotein; Reference proteome; Secreted.
FT   CHAIN           1..199
FT                   /note="Prolactin"
FT                   /id="PRO_0000181319"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        4..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..174
FT                   /evidence="ECO:0000250"
FT   DISULFID        191..199
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   199 AA;  22673 MW;  6C43457310B9CCE7 CRC64;
     IPVCPRGSVR CQVSLPDLFD RAVMLSHYIH SLSSDMFHEF NKQYALGRGF IPRAINSCHT
     SSISTPEDKD QAQQTHHEVL MDLILGLLRS WNDPLDHLAS EVHSLPKAPS ALLTKATEVK
     EENQRLLEGI EKIVDQVHPG AKENKAYSVW SGLPSLQTTD EDARLFAFYN LFRCLRRDSH
     KIDSYLKLLK CRIVYNNNC