ID   PRL_MACMU               Reviewed;         227 AA.
AC   P55151;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Decidua;
RX   PubMed=8167226; DOI=10.1095/biolreprod50.3.543;
RA   Brown N.A., Bethea C.L.;
RT   "Cloning of decidual prolactin from rhesus macaque.";
RL   Biol. Reprod. 50:543-552(1994).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U09018; AAA18471.1; -; mRNA.
DR   RefSeq; NP_001040593.1; NM_001047128.2.
DR   RefSeq; XP_014991125.1; XM_015135639.1.
DR   AlphaFoldDB; P55151; -.
DR   BMRB; P55151; -.
DR   SMR; P55151; -.
DR   STRING; 9544.ENSMMUP00000027172; -.
DR   GeneID; 707052; -.
DR   KEGG; mcc:707052; -.
DR   CTD; 5617; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; P55151; -.
DR   OMA; NEVYSRW; -.
DR   TreeFam; TF332592; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Lactation; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..227
FT                   /note="Prolactin"
FT                   /id="PRO_0000032917"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         62
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         118
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..202
FT                   /evidence="ECO:0000250"
FT   DISULFID        219..227
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25972 MW;  1B6B25E087C401E4 CRC64;
     MNIKGSPWKG SLLLLLVSNL LLCQNVAPLP ICPGGAARCQ VTLRDLFDRA VVLSHYIHNL
     SSEMFSEFDK RYTHGRGFIT RAINSCHTSS LPTPEDKEQA QQMNQKDFLS LIVSILRSWN
     EPLYHLVTEV RGMEEAPEAI LSKAVEIEEQ TKRLLEGMEL IVSQVHPETK ENEIYPVWTG
     LPSLQMADEE SRLSAYYNLL HCLRRDSHKI DNYLKLLKCR IIHNNNC