ID   PRL_MESAU               Reviewed;         226 AA.
AC   P37884;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1954881; DOI=10.1210/endo-129-6-2965;
RA   Southard J.N., Sanchez-Jimenez F., Campbell G.T., Talamantes F.;
RT   "Sequence and expression of hamster prolactin and growth hormone messenger
RT   RNAs.";
RL   Endocrinology 129:2965-2971(1991).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S66296; AAB20367.1; -; mRNA.
DR   PIR; A49159; A49159.
DR   RefSeq; NP_001268581.1; NM_001281652.1.
DR   AlphaFoldDB; P37884; -.
DR   SMR; P37884; -.
DR   STRING; 10036.XP_005066495.1; -.
DR   GeneID; 101843376; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   OrthoDB; 1290070at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   CHAIN           30..226
FT                   /note="Prolactin"
FT                   /id="PRO_0000032918"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         117
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        33..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..201
FT                   /evidence="ECO:0000250"
FT   DISULFID        218..226
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   226 AA;  25582 MW;  2AD7B129612DCFCD CRC64;
     MNSQGSDRKA VTLLLLVMSN LLFCQNAHPL PICPGGNCQM PLQELFDRVI MLSHYIYMLS
     ADMFIELDKQ YAQDHEFIAK AISDCPTSSL ATPEGKEEAQ QVPPEVLLNL ILSLVHSWND
     PLFQLVTEVD GIHEASDAII SRAKEIGEQN KRLLEGIEKI LGQAYPEAKG NEIYSVWSQF
     PSLQGVDEES RDLAIYNKVR CLRRDSHKVD NYLKLLRCRV VHNNNC