ID   PRL_MICMO               Reviewed;         225 AA.
AC   Q9QZL1;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Microtus montebelli (Japanese grass vole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Arvicolinae; Microtus.
OX   NCBI_TaxID=79202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ohboshi S., Asami W., Kaneko M., Yoshida S., Yoshida T., Tomogane H.;
RT   "Sequencing of prolactin cDNA of Japanese field vole.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF178933; AAD53180.1; -; mRNA.
DR   AlphaFoldDB; Q9QZL1; -.
DR   SMR; Q9QZL1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..225
FT                   /note="Prolactin"
FT                   /id="PRO_0000032919"
FT   MOD_RES         52
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        32..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..200
FT                   /evidence="ECO:0000250"
FT   DISULFID        217..225
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   225 AA;  25720 MW;  323383E8407085BA CRC64;
     MTIQGSDRKG TLLLLVMSNL LFCQNVHPLP ICHSGNCQMT LQELFDRVIM LSHYVYMMSA
     DMFIEFEKRY AQDHEFIAKA INDCPTSSLA TPEDKEEAQQ VPPEVLLNLI LSLVHSWNGP
     LFQLVTEVDG IHEASDAIIS RAKEIGEQNK RLLEGIEKIL GQAYPEAKGN EVYSVWSQFP
     SLQGIDEESR DLALYNKIRC LRRDSHKVDN YLKLLRCRIV HNNNC