ID   PRL_MONDO               Reviewed;         228 AA.
AC   O62819;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Kacsoh B., Soos G.;
RT   "Cloning and characterization of pituitary prolactin cDNA from the
RT   marsupial Monodelphis domestica.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF067726; AAC18398.1; -; mRNA.
DR   RefSeq; NP_001028166.1; NM_001032994.1.
DR   AlphaFoldDB; O62819; -.
DR   SMR; O62819; -.
DR   STRING; 13616.ENSMODP00000014194; -.
DR   GeneID; 100017831; -.
DR   KEGG; mdo:100017831; -.
DR   CTD; 5617; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; O62819; -.
DR   OrthoDB; 1290070at2759; -.
DR   Proteomes; UP000002280; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   CHAIN           30..228
FT                   /note="Prolactin"
FT                   /id="PRO_0000032920"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        33..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..203
FT                   /evidence="ECO:0000250"
FT   DISULFID        220..228
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   228 AA;  26071 MW;  4DA2D906EF333EA9 CRC64;
     MCPKGSSVKG SLLLLLLMSS RFLFKAVESL PICPSGAVNC QVSLSDLFDR AVMLSHYIHS
     PSSEMFNEFD ERYAQGRGFI TKAINSCHTS SLSTPEDKEQ AQQIRHEDLL NLVLRVLRSW
     SEPLYHLVTE VRSMQEAPDT ILLKAMEIEE QNKRLLEGME KIVGQVHPGD RENEVYSVWS
     GLPSLQMADE DTRLFAFYNL LHCLRRDSHK IDNYLKLLKC RLIHDSNC