ID   PRL_NEOVI               Reviewed;         229 AA.
AC   P29234; Q864R8;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 3.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Vardy T.L., Farid A.;
RT   "Nucleotide sequence variation of the mink preprolactin gene.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 37-229.
RX   PubMed=8307350;
RA   Perelygina L.M., Baricheva E.M., Sebeleva T.E., Kokoza V.A.;
RT   "The evolutionarily conserved gene Nc70F, expressed in nerve tissue of
RT   Drosophila melanogaster, encodes a protein homologous to the mouse delta
RT   transcription factor.";
RL   Genetika 29:1597-1607(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 55-229.
RC   TISSUE=Pituitary;
RA   Bondar A.A., Golovin S.J., Mertvetsov N.P.;
RT   "Nucleotide sequence of mink prolactin mRNA from pituitary.";
RL   Sibirskii Biol. Zh. 2:10-15(1993).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AY249860; AAO92934.1; -; Genomic_DNA.
DR   EMBL; X59785; CAA42447.1; -; mRNA.
DR   EMBL; X63235; CAA44910.1; -; mRNA.
DR   PIR; S18882; S18882.
DR   AlphaFoldDB; P29234; -.
DR   SMR; P29234; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..229
FT                   /note="Prolactin"
FT                   /id="PRO_0000032922"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         120
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        34..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
FT   CONFLICT        76
FT                   /note="Q -> H (in Ref. 2; CAA42447)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="D -> E (in Ref. 2; CAA42447)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226
FT                   /note="D -> H (in Ref. 2; CAA42447)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   229 AA;  26194 MW;  D3ADDB618CCA29BC CRC64;
     MDNKGWSLKG SLLPLLLLVS DLLLCQGVTS LPICPTGAVN CQVSLRDLFD RAVILSHYIH
     NLSSEMFNEF DKRYAQGRGF ITKAINSCHT SSLSTPEDKE QAQQIHHEDL LNLILRVLRS
     WNDPLYHLVS EVRGMQEAPD SILSRAIEIE EQNRRLLEGM EKIVGQVHPG VRENEVYSVW
     SGLPSLQMAD EDSRLFAFYN LLHCLRRDSH KIDNYLKLLK CRIVYDSNC