ID   PRL_ONCMY               Reviewed;         210 AA.
AC   P21993;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2647439; DOI=10.1089/dna.1.1989.8.119;
RA   Mercier L., Rentier-Delrue F., Swennen D., Lion M., le Goff P., Prunet P.,
RA   Martial J.A.;
RT   "Rainbow trout prolactin cDNA cloning in Escherichia coli.";
RL   DNA 8:119-125(1989).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M24738; AAA49611.1; -; mRNA.
DR   PIR; A31364; A31364.
DR   RefSeq; NP_001118205.1; NM_001124733.1.
DR   AlphaFoldDB; P21993; -.
DR   SMR; P21993; -.
DR   Ensembl; ENSOMYT00000057858; ENSOMYP00000053184; ENSOMYG00000024343.
DR   GeneID; 100136792; -.
DR   KEGG; omy:100136792; -.
DR   CTD; 5617; -.
DR   GeneTree; ENSGT00950000182818; -.
DR   OrthoDB; 1290070at2759; -.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; IMP:AgBase.
DR   GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; ISS:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISS:AgBase.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; IDA:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; ISS:AgBase.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:AgBase.
DR   GO; GO:0060267; P:positive regulation of respiratory burst; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   GO; GO:0043434; P:response to peptide hormone; IMP:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..210
FT                   /note="Prolactin"
FT                   /id="PRO_0000032941"
FT   DISULFID        69..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..210
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23366 MW;  6BC8E046486E0A34 CRC64;
     MARRSQGTKL HLAVLCLVVS CHAIGLSDLM ERASQRSDKL HSLSTSLTKD LDSHFPPMGR
     VMMPRPSMCH TSSLQTPKDK EQALKVSENE LISLARSLLL AWNDPLLLLS SEAPTLPHPS
     NGDISSKIRE LQDYSKSLGD GLDIMVNKMG PSSQYISSIP FKGGDLGNDK TSRLINFHFL
     MSCFRRDSHK IDSFLKVLRC RATKMRPEAC