ID   PRL_PAROL               Reviewed;         211 AA.
AC   Q9YGV6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kim Y.T., Lee S.Y.;
RT   "Flounder prolactin.";
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF047616; AAD15746.1; -; mRNA.
DR   RefSeq; XP_019966165.1; XM_020110606.1.
DR   AlphaFoldDB; Q9YGV6; -.
DR   SMR; Q9YGV6; -.
DR   GeneID; 109645096; -.
DR   KEGG; pov:109645096; -.
DR   CTD; 5617; -.
DR   OrthoDB; 1290070at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..211
FT                   /note="Prolactin"
FT                   /id="PRO_0000032946"
FT   DISULFID        70..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..211
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   211 AA;  23340 MW;  06D5800CB6756D8F CRC64;
     MTHRRTKLFM MAAVVSYVMT SCGAVPINDL LDRASQRSDQ LHSLSTTLSQ ELDSHFPPIG
     RVIMPRPSMC HTSALQTPND KTQALQVSES ELLSLARSLL QAWADPLSAL SSSAFSLPHP
     AQSSIFNKVR EMQEHSKNLG DGLDILSGKM GEAAQALSSL PFRGNDVGQD RISKLINFHF
     LLSCFRRDSH KIDSFLKVLR CRAANTQPEM C